{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:13:37Z","timestamp":1778872417369,"version":"3.51.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"25","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,6,27]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Arterial remodeling after balloon angioplasty has been recognized as a major determinant of restenosis. Perturbation of collagen metabolism might be important. After balloon injury, matrix metalloproteinase (MMP) expression is upregulated. We investigated the effect of Batimastat, a nonspecific MMP inhibitor, on late lumen loss, arterial remodeling, and neointima formation after balloon dilation.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014In atherosclerotic iliac arteries of 12 Yucatan micropigs, balloon dilation was performed, with intravascular ultrasound and quantitative angiography used before and after balloon dilation and at 42-day follow-up. The animals were randomly divided into 2 groups, the Batimastat group (n=6) and the vehicle group (n=6). All animals were intraperitoneally injected with either Batimastat or a vehicle immediately after balloon dilation and at 2 weeks and 4 weeks after balloon dilation. Angiographic and echographic late lumen loss in the Batimastat group versus the vehicle group was 0.3\u00b10.1 versus 0.8\u00b10.1 mm (\n            <jats:italic>P<\/jats:italic>\n            =0.01) and 2.2\u00b10.5 versus 4.9\u00b10.7 mm\n            <jats:sup>2<\/jats:sup>\n            (\n            <jats:italic>P<\/jats:italic>\n            =0.004), respectively. Late media-bounded area loss was used as a measure of remodeling after balloon dilation and was 0.9\u00b10.6 mm\n            <jats:sup>2<\/jats:sup>\n            in the Batimastat group compared with 3.8\u00b10.8 mm\n            <jats:sup>2<\/jats:sup>\n            in the vehicle group (\n            <jats:italic>P<\/jats:italic>\n            =0.003, mixed model analysis\n            <jats:italic>P<\/jats:italic>\n            =0.01). Neointima formation was 1.3\u00b10.3 mm\n            <jats:sup>2<\/jats:sup>\n            in the Batimastat group and 1.0\u00b10.2 mm\n            <jats:sup>2<\/jats:sup>\n            in the vehicle group (\n            <jats:italic>P<\/jats:italic>\n            =0.542).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Metalloproteinase inhibition by Batimastat significantly reduced late lumen loss after balloon angioplasty by inhibition of constrictive arterial remodeling, whereas neointima formation was not inhibited by MMP inhibition.\n          <\/jats:p>","DOI":"10.1161\/01.cir.101.25.2962","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"2962-2967","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":67,"title":["Metalloproteinase Inhibition Reduces Constrictive Arterial Remodeling After Balloon Angioplasty"],"prefix":"10.1161","volume":"101","author":[{"given":"Bart J. G. L.","family":"de Smet","sequence":"first","affiliation":[{"name":"From the Heart Lung Institute (B.J.G.L.d.S., D.d.K., L.R., Y.J.M.v.d.H., C.B., M.J.P.), Utrecht University Hospital, and the Interuniversity Cardiology Institute of the Netherlands (B.J.G.L.d.S., D.d.K., M.J.P.), Utrecht, the Netherlands; the Angiogenesis Research Center (M.J.P.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass; and Gaubius Laboratory (R.H., J.H.V.), TNO Prevention and Health, Leiden, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"de Kleijn","sequence":"additional","affiliation":[{"name":"From the Heart Lung Institute (B.J.G.L.d.S., D.d.K., L.R., Y.J.M.v.d.H., C.B., M.J.P.), Utrecht University Hospital, and the Interuniversity Cardiology Institute of the Netherlands (B.J.G.L.d.S., D.d.K., M.J.P.), Utrecht, the Netherlands; the Angiogenesis Research Center (M.J.P.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass; and Gaubius Laboratory (R.H., J.H.V.), TNO Prevention and Health, Leiden, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roeland","family":"Hanemaaijer","sequence":"additional","affiliation":[{"name":"From the Heart Lung Institute (B.J.G.L.d.S., D.d.K., L.R., Y.J.M.v.d.H., C.B., M.J.P.), Utrecht University Hospital, and the Interuniversity Cardiology Institute of the Netherlands (B.J.G.L.d.S., D.d.K., M.J.P.), Utrecht, the Netherlands; the Angiogenesis Research Center (M.J.P.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass; and Gaubius Laboratory (R.H., J.H.V.), TNO Prevention and Health, Leiden, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan H.","family":"Verheijen","sequence":"additional","affiliation":[{"name":"From the Heart Lung Institute (B.J.G.L.d.S., D.d.K., L.R., Y.J.M.v.d.H., C.B., M.J.P.), Utrecht University Hospital, and the Interuniversity Cardiology Institute of the Netherlands (B.J.G.L.d.S., D.d.K., M.J.P.), Utrecht, the Netherlands; the Angiogenesis Research Center (M.J.P.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass; and Gaubius Laboratory (R.H., J.H.V.), TNO Prevention and Health, Leiden, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Robertus","sequence":"additional","affiliation":[{"name":"From the Heart Lung Institute (B.J.G.L.d.S., D.d.K., L.R., Y.J.M.v.d.H., C.B., M.J.P.), Utrecht University Hospital, and the Interuniversity Cardiology Institute of the Netherlands (B.J.G.L.d.S., D.d.K., M.J.P.), Utrecht, the Netherlands; the Angiogenesis Research Center (M.J.P.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass; and Gaubius Laboratory (R.H., J.H.V.), TNO Prevention and Health, Leiden, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne J. M.","family":"van der Helm","sequence":"additional","affiliation":[{"name":"From the Heart Lung Institute (B.J.G.L.d.S., D.d.K., L.R., Y.J.M.v.d.H., C.B., M.J.P.), Utrecht University Hospital, and the Interuniversity Cardiology Institute of the Netherlands (B.J.G.L.d.S., D.d.K., M.J.P.), Utrecht, the Netherlands; the Angiogenesis Research Center (M.J.P.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass; and Gaubius Laboratory (R.H., J.H.V.), TNO Prevention and Health, Leiden, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius","family":"Borst","sequence":"additional","affiliation":[{"name":"From the Heart Lung Institute (B.J.G.L.d.S., D.d.K., L.R., Y.J.M.v.d.H., C.B., M.J.P.), Utrecht University Hospital, and the Interuniversity Cardiology Institute of the Netherlands (B.J.G.L.d.S., D.d.K., M.J.P.), Utrecht, the Netherlands; the Angiogenesis Research Center (M.J.P.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass; and Gaubius Laboratory (R.H., J.H.V.), TNO Prevention and Health, Leiden, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Post","sequence":"additional","affiliation":[{"name":"From the Heart Lung Institute (B.J.G.L.d.S., D.d.K., L.R., Y.J.M.v.d.H., C.B., M.J.P.), Utrecht University Hospital, and the Interuniversity Cardiology Institute of the Netherlands (B.J.G.L.d.S., D.d.K., M.J.P.), Utrecht, the Netherlands; the Angiogenesis Research Center (M.J.P.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass; and Gaubius Laboratory (R.H., J.H.V.), TNO Prevention and Health, Leiden, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.1.35"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80409-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.6.8205696"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.6.8205695"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.76.6.996"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.3.996"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.79.3.541"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","unstructured":"Post MJ Pasterkamp G Borst C. 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