{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:45:39Z","timestamp":1785545139003,"version":"3.56.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Alcohol consumption may be linked to syncopal events. The mechanisms by which alcohol may induce syncope are unknown. Impairment of the response to orthostatic stress may be involved. Using a double-blind, randomized, placebo-controlled study, we tested the hypothesis that short-term alcohol intake causes orthostatic hypotension because of an impairment in the vasoconstrictor response to orthostatic stress.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014We examined the effects of alcohol on blood pressure, heart rate, and forearm vascular resistance (FVR) during orthostatic stress achieved by stepwise increases in lower-body negative pressure (LBNP) in 14 healthy young volunteers. During the placebo session, blood pressure did not change significantly during LBNP at \u22125, \u221210, and \u221220 mm Hg. A significant decrease in blood pressure was evident only at \u221240 mm Hg. In contrast, blood pressure fell significantly at all levels of LBNP during the alcohol session. Compared with placebo, alcohol potentiated the hypotensive responses to LBNP, particularly at \u221240 mm Hg, when the decrease in systolic blood pressure after alcohol intake (\u221214 mm Hg) was double that after placebo intake (\u22127 mm Hg). FVR increased with LBNP after placebo. However, after alcohol intake, FVR did not increase during LBNP despite the potentiated decrease in blood pressure. FVR responses during LBNP were reduced during alcohol compared with placebo consumption (\n            <jats:italic>P<\/jats:italic>\n            =0.04).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Short-term alcohol consumption elicits hypotension during orthostatic stress because of impairment of vasoconstriction. These findings have implications for the understanding of the hemodynamic effects of alcohol and, in particular, for understanding syncopal events that occur in association with alcohol intake.\n          <\/jats:p>","DOI":"10.1161\/01.cir.101.4.398","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"398-402","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Alcohol Potentiates Orthostatic Hypotension"],"prefix":"10.1161","volume":"101","author":[{"given":"Krzysztof","family":"Narkiewicz","sequence":"first","affiliation":[{"name":"From the Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan L.","family":"Cooley","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virend K.","family":"Somers","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80227-7"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100119316"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1958.03000090030007"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(86)90094-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196111162652004"},{"key":"e_1_3_2_6_2","first-page":"583","volume":"84","year":"1992","unstructured":"Burke V, Beilin LJ, German R, Grosskopf S, Ritchie J, Puddey IB, Rogers P. 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Neurology. 1994;241:145\u2013152.","journal-title":"Neurology"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-2-171"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","unstructured":"Hayoz D Noll G Passino C Weber R Wenzel R Bernardi L. Progressive withdrawal of muscle nerve sympathetic activity preceding vasovagal syncope during lower-body negative pressure. Clin Sci. 1996;91(suppl):50\u201351.","DOI":"10.1042\/cs0910050supp"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119463"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.8.2509"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0720113"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/22.3.226"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.14.5.511"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.101.4.398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T12:58:32Z","timestamp":1715518712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.101.4.398"}},"subtitle":["Implications for Alcohol-Related Syncope"],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["10.1161\/01.CIR.101.4.398"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.101.4.398","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,2]]},"assertion":[{"value":"1999-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-09-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}