{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:43:22Z","timestamp":1790459002546,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,2,8]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>\u2014Physiological blood pressure (BP) fluctuations with frequencies &gt;0.1 Hz can override renal blood flow autoregulation. The influence of such immediate changes in renal perfusion pressure (RPP) on daily BP regulation, eg, via shear stress\u2013stimulated liberation of renal endothelial NO, however, is unknown. Thus, we studied the effects of such RPP oscillations on renal function and on systemic BP during the onset of renal hypertension.<\/jats:p><jats:p><jats:italic>Methods and Results<\/jats:italic>\u2014Seven beagles (randomly assigned to each of the following protocols) were chronically instrumented for the measurement of systemic BP, RPP, and renal excretory function. An inflatable cuff was used to reduce and to oscillate RPP over 24 hours in the freely moving dog. Reducing RPP to 87\u00b12 mm Hg diminished excretion of sodium and water and doubled plasma renin activity (PRA, n=7,<jats:italic>P<\/jats:italic>&lt;0.01) but had no significant effect on urinary nitrate excretion (n=6), a marker of NO generation. Superimposing 0.1-Hz oscillations (\u00b110 mm Hg) onto the reduced RPP blunted hypertension, returned fluid excretion almost to control levels, and doubled renal sodium elimination. Nitrate excretion peaked at 8 hours, only to return to control values shortly thereafter. PRA, conversely, was significantly reduced during the last third of the experimental protocols.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>\u2014BP fluctuations transiently stimulate NO liberation and induce a reduction in PRA, which enhances 24-hour sodium and water excretion and markedly attenuates the acute development of renovascular hypertension.<\/jats:p>","DOI":"10.1161\/01.cir.101.5.553","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"553-557","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Antihypertensive Effect of 0.1-Hz Blood Pressure Oscillations to the Kidney"],"prefix":"10.1161","volume":"101","author":[{"given":"Benno","family":"Nafz","sequence":"first","affiliation":[{"name":"From the Institut fu\u0308r Physiologie (B.N., J.S., E.S., H.W.R., P.B.P.) and the Institut fu\u0308r klinische Chemie (N.R., I.S.) der Humboldt Universita\u0308t Berlin, Berlin, Germany, and the Department of Medical Physiology, University of Copenhagen Panum Institute, Copenhagen, Denmark (M.H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Stegemann","sequence":"additional","affiliation":[{"name":"From the Institut fu\u0308r Physiologie (B.N., J.S., E.S., H.W.R., P.B.P.) and the Institut fu\u0308r klinische Chemie (N.R., I.S.) der Humboldt Universita\u0308t Berlin, Berlin, Germany, and the Department of Medical Physiology, University of Copenhagen Panum Institute, Copenhagen, Denmark (M.H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morton H.","family":"Bestle","sequence":"additional","affiliation":[{"name":"From the Institut fu\u0308r Physiologie (B.N., J.S., E.S., H.W.R., P.B.P.) and the Institut fu\u0308r klinische Chemie (N.R., I.S.) der Humboldt Universita\u0308t Berlin, Berlin, Germany, and the Department of Medical Physiology, University of Copenhagen Panum Institute, Copenhagen, Denmark (M.H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Richter","sequence":"additional","affiliation":[{"name":"From the Institut fu\u0308r Physiologie (B.N., J.S., E.S., H.W.R., P.B.P.) and the Institut fu\u0308r klinische Chemie (N.R., I.S.) der Humboldt Universita\u0308t Berlin, Berlin, Germany, and the Department of Medical Physiology, University of Copenhagen Panum Institute, Copenhagen, Denmark (M.H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdmann","family":"Seeliger","sequence":"additional","affiliation":[{"name":"From the Institut fu\u0308r Physiologie (B.N., J.S., E.S., H.W.R., P.B.P.) and the Institut fu\u0308r klinische Chemie (N.R., I.S.) der Humboldt Universita\u0308t Berlin, Berlin, Germany, and the Department of Medical Physiology, University of Copenhagen Panum Institute, Copenhagen, Denmark (M.H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingolf","family":"Schimke","sequence":"additional","affiliation":[{"name":"From the Institut fu\u0308r Physiologie (B.N., J.S., E.S., H.W.R., P.B.P.) and the Institut fu\u0308r klinische Chemie (N.R., I.S.) der Humboldt Universita\u0308t Berlin, Berlin, Germany, and the Department of Medical Physiology, University of Copenhagen Panum Institute, Copenhagen, Denmark (M.H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Wolfgang","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"From the Institut fu\u0308r Physiologie (B.N., J.S., E.S., H.W.R., P.B.P.) and the Institut fu\u0308r klinische Chemie (N.R., I.S.) der Humboldt Universita\u0308t Berlin, Berlin, Germany, and the Department of Medical Physiology, University of Copenhagen Panum Institute, Copenhagen, Denmark (M.H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pontus B.","family":"Persson","sequence":"additional","affiliation":[{"name":"From the Institut fu\u0308r Physiologie (B.N., J.S., E.S., H.W.R., P.B.P.) and the Institut fu\u0308r klinische Chemie (N.R., I.S.) der Humboldt Universita\u0308t Berlin, Berlin, Germany, and the Department of Medical Physiology, University of Copenhagen Panum Institute, Copenhagen, Denmark (M.H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"1635","volume":"23","year":"1990","unstructured":"Sytkowski PA, Kannel WB, D\u2019Agostino RB. 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