{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:03:58Z","timestamp":1791025438368,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,9,12]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014The stratification of post\u2013myocardial infarction (MI) patients at risk of sudden cardiac death remains important. The aim of the present study was to assess the prognostic value of novel T-wave morphology descriptors derived from resting 12-lead ECGs.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014In 280 consecutive post-MI patients, a 12-lead ECG was recorded before discharge, optically scanned, and digitized. For the present study, 5 T-wave morphology descriptors were automatically calculated after singular value decomposition of the ECG signal. The total cosine R-to-T (TCRT [describes the global angle between repolarization and depolarization wavefront]) and the T-wave loop dispersion were univariately associated (\n            <jats:italic>P<\/jats:italic>\n            =0.0002 and\n            <jats:italic>P<\/jats:italic>\n            &lt;0.002, respectively,\n            <jats:italic>U<\/jats:italic>\n            test) with 27 prospectively defined clinical events in 261 patients (mean follow-up 32\u00b110 months). Kaplan-Meier event probability curves for strata above and below the median confirmed the strong risk discrimination by TCRT and T-wave loop dispersion (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.003 and\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001, respectively, log-rank test). On Cox regression analysis, with the entering of age, left ventricular ejection fraction, heart rate, QRS width, reperfusion therapy, \u03b2-adrenergic\u2013blocker treatment, and standard deviation of R-R intervals on 24-hour Holter monitoring, TCRT (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.03) yielded independent predictive value, whereas T-wave loop dispersion was of borderline independence (\n            <jats:italic>P<\/jats:italic>\n            =0.064). Heart rate (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.02), left ventricular ejection fraction (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.02), and reperfusion therapy (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.02) also remained in the final model.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Computerized T-wave morphology analysis of the 12-lead resting ECG permits independent assessment of post-MI risk and an improved risk stratification when combined with other risk markers.\n          <\/jats:p>","DOI":"10.1161\/01.cir.102.11.1252","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"1252-1257","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":195,"title":["Analysis of 12-Lead T-Wave Morphology for Risk Stratification After Myocardial Infarction"],"prefix":"10.1161","volume":"102","author":[{"given":"Markus","family":"Zabel","sequence":"first","affiliation":[{"name":"From the Cardiology Division (M.Z.), Klinikum Benjamin Franklin, Free University, Berlin, Germany; Cardiological Sciences (B.A., M.M.), St George\u2019s Hospital Medical School, London, England; Cardiology Division (T.K., S.H.H.), J.W. Goethe University, Frankfurt, Germany; and Cardiology Division (M.R.F.), VA Medical Center and Georgetown University, Washington, DC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Acar","sequence":"additional","affiliation":[{"name":"From the Cardiology Division (M.Z.), Klinikum Benjamin Franklin, Free University, Berlin, Germany; Cardiological Sciences (B.A., M.M.), St George\u2019s Hospital Medical School, London, England; Cardiology Division (T.K., S.H.H.), J.W. Goethe University, Frankfurt, Germany; and Cardiology Division (M.R.F.), VA Medical Center and Georgetown University, Washington, DC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klingenheben","sequence":"additional","affiliation":[{"name":"From the Cardiology Division (M.Z.), Klinikum Benjamin Franklin, Free University, Berlin, Germany; Cardiological Sciences (B.A., M.M.), St George\u2019s Hospital Medical School, London, England; Cardiology Division (T.K., S.H.H.), J.W. Goethe University, Frankfurt, Germany; and Cardiology Division (M.R.F.), VA Medical Center and Georgetown University, Washington, DC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Franz","sequence":"additional","affiliation":[{"name":"From the Cardiology Division (M.Z.), Klinikum Benjamin Franklin, Free University, Berlin, Germany; Cardiological Sciences (B.A., M.M.), St George\u2019s Hospital Medical School, London, England; Cardiology Division (T.K., S.H.H.), J.W. Goethe University, Frankfurt, Germany; and Cardiology Division (M.R.F.), VA Medical Center and Georgetown University, Washington, DC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H.","family":"Hohnloser","sequence":"additional","affiliation":[{"name":"From the Cardiology Division (M.Z.), Klinikum Benjamin Franklin, Free University, Berlin, Germany; Cardiological Sciences (B.A., M.M.), St George\u2019s Hospital Medical School, London, England; Cardiology Division (T.K., S.H.H.), J.W. Goethe University, Frankfurt, Germany; and Cardiology Division (M.R.F.), VA Medical Center and Georgetown University, Washington, DC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Malik","sequence":"additional","affiliation":[{"name":"From the Cardiology Division (M.Z.), Klinikum Benjamin Franklin, Free University, Berlin, Germany; Cardiological Sciences (B.A., M.M.), St George\u2019s Hospital Medical School, London, England; Cardiology Division (T.K., S.H.H.), J.W. 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