{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:16:46Z","timestamp":1791281806021,"version":"4.1.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,9,19]]},"abstract":"\n Background<\/jats:italic>\n \u2014Hypertrophic cardiomyopathy (HCM) is diagnosed clinically by the presence of left ventricular hypertrophy (LVH). However, LVH is absent in a significant number of genotype-positive patients. Because myocyte dysfunction and disarray are the primary abnormalities in HCM, we reasoned that tissue Doppler imaging could identify contraction and relaxation abnormalities, irrespective of hypertrophy, in a transgenic rabbit model of human HCM.\n <\/jats:p>\n \n Methods and Results<\/jats:italic>\n \u2014M-mode, 2D, Doppler echocardiography and tissue Doppler imaging were performed in nontransgenic (n=24), wild-type \u03b2-myosin heavy chain-arginine\n 403<\/jats:sup>\n (n=14), and mutant \u03b2-myosin heavy chain-glutamic acid\n 403<\/jats:sup>\n (n=24) transgenic rabbits. Mean septal thicknesses were 2.0\u00b10.3, 2.0\u00b10.25, and 2.75\u00b10.3 mm in the 3 groups, respectively (\n P<\/jats:italic>\n =0.001). LVH was absent in 9 of the 24 mutant rabbits. Left ventricular dimensions, systolic function, heart rate, mitral inflow velocities, and time intervals were similar in the groups. However, the difference between atrial reversal and transmitral A wave duration was increased in the mutant rabbits (\n P<\/jats:italic>\n <0.001). More importantly, systolic and early diastolic tissue Doppler velocities were significantly lower in all mutant rabbits (7.45\u00b12.2 versus 10.8\u00b12.3 cm\/s in nontransgenic and 9.0\u00b10.76 cm\/s in wild-type;\n P<\/jats:italic>\n <0.001), including the 9 without LVH. A systolic velocity <8.5 cm\/s had an 86% sensitivity and 100% specificity in identifying the mutant transgenic rabbits.\n <\/jats:p>\n \n Conclusions<\/jats:italic>\n \u2014Myocardial contraction and relaxation were reduced in the mutant \u03b2-myosin heavy chain-glutamic acid\n 403<\/jats:sup>\n transgenic rabbit model of human HCM, irrespective of the presence or absence of LVH. In addition, tissue Doppler imaging is more sensitive than conventional echocardiography for HCM screening.\n <\/jats:p>","DOI":"10.1161\/01.cir.102.12.1346","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"1346-1350","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":130,"title":["Tissue Doppler Imaging Consistently Detects Myocardial Contraction and Relaxation Abnormalities, Irrespective of Cardiac Hypertrophy, in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy"],"prefix":"10.1161","volume":"102","author":[{"given":"Sherif F.","family":"Nagueh","sequence":"first","affiliation":[{"name":"From the Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen A.","family":"Kopelen","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Sun","family":"Lim","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Zoghbi","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Quin\u0303ones","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Roberts","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali J.","family":"Marian","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Seidman CE Seidman JG. Molecular genetics of inherited cardiomyopathies. In: Chien KR ed. Molecular Basis of Cardiovascular Disease. Philadelphia Pa: Saunders; 1999:251\u2013263."},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804303381802"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204233261703"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.4.700"},{"key":"e_1_3_2_5_2","first-page":"542","volume":"45","year":"1997","unstructured":"Brugada R, Kelsey W, Lechin M, et al. Role of candidate modifier genes on the phenotypic expression of hypertrophy in patients with hypertrophic cardiomyopathy. J Investig Med. 1997;45:542\u2013551.","journal-title":"J Investig Med"},{"key":"e_1_3_2_6_2","first-page":"191","volume":"45","year":"1997","unstructured":"Abchee A, Marian AJ. Prognostic significance of beta-myosin heavy chain mutations is reflective of their hypertrophic expressivity in patients with hypertrophic cardiomyopathy. J Investig Med. 1997;45:191\u2013196.","journal-title":"J Investig Med"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.81.1.76"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6377"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.5.H1780"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)06187-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7956"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.99.2.254"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","unstructured":"Severino S Caso P Galderisi M et al. Use of pulsed Doppler tissue imaging to assess regional left ventricular diastolic dysfunction in hypertrophic cardiomyopathy. Am J Cardiol. 1998 82;1394\u20131398.","DOI":"10.1016\/S0002-9149(98)00648-1"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.102.12.1346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T13:13:16Z","timestamp":1715519596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.102.12.1346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,19]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2000,9,19]]}},"alternative-id":["10.1161\/01.CIR.102.12.1346"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.102.12.1346","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9,19]]},"assertion":[{"value":"2000-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-06-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}