{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:49:58Z","timestamp":1790934598744,"version":"4.1.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,9,26]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Because complete linear conduction block is necessary to minimize the recurrence of reentrant tachycardias such as typical atrial flutter, we investigated a simple technique to recognize a persistent gap or complete linear block.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014We prospectively evaluated cavotricuspid isthmus conduction in 50 patients (age 63\u00b18 years, 43 men) after radiofrequency ablation. The distal and proximal bipoles of a quadripolar catheter placed close to the ablation line were successively stimulated during recording from the ablation line. We hypothesized that because the initial and terminal components of local potentials reflected activation at the ipsilateral and contralateral borders of the ablation lesion, a change to a more proximal pacing site without moving the catheter would prolong the stimulus to the initial component timing, whereas the response of the terminal component would depend on the presence of block or persistent conduction. A shortening or no change in timing of the terminal component would indicate block, whereas lengthening would indicate persistent gap conduction. The results were compared with previously described criteria for isthmus block. Ninety-two sites were assessed: 17 before and 75 after the achievement of complete isthmus block. The timing of the initial component was delayed by 19\u00b19 ms, and the terminal component was advanced by 13\u00b18 ms after block and delayed by 12\u00b19 ms in case of persisting conduction. The sensitivity, specificity, and positive and negative predictive values for linear block were 100%, 75%, 94%, and 100%, respectively.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014An accurate assessment of isthmus block or persistent isthmus conduction is possible with this technique of differential pacing.\n          <\/jats:p>","DOI":"10.1161\/01.cir.102.13.1517","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"1517-1522","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":167,"title":["Differential Pacing for Distinguishing Block From Persistent Conduction Through an Ablation Line"],"prefix":"10.1161","volume":"102","author":[{"given":"Dipen","family":"Shah","sequence":"first","affiliation":[{"name":"From the De\u0301partement de Rythmologie, Ho\u0302pital Cardiologique du Haut-Le\u0301ve\u0302que, Bordeaux-Pessac, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Hai\u0308ssaguerre","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Rythmologie, Ho\u0302pital Cardiologique du Haut-Le\u0301ve\u0302que, Bordeaux-Pessac, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Rythmologie, Ho\u0302pital Cardiologique du Haut-Le\u0301ve\u0302que, Bordeaux-Pessac, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Jai\u0308s","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Rythmologie, Ho\u0302pital Cardiologique du Haut-Le\u0301ve\u0302que, Bordeaux-Pessac, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Me\u0301le\u0300ze","family":"Hocini","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Rythmologie, Ho\u0302pital Cardiologique du Haut-Le\u0301ve\u0302que, Bordeaux-Pessac, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Cle\u0301menty","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Rythmologie, Ho\u0302pital Cardiologique du Haut-Le\u0301ve\u0302que, Bordeaux-Pessac, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Waldo AL. Atrial flutter: mechanisms clinical features and management. In: Zipes DP Jalife J eds. Cardiac Electrophysiology: From Cell to Bedside 2nd ed. Philadelphia Pa: WB Saunders; 1995:666\u2013681."},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)91014-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.86.4.1394929"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.93.2.284"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.6.1389"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.3.407"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb00243.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.8.2505"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.101.7.772"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"Kottkamp H Hindricks G. Catheter ablation of atrial flutter. Thorac Cardiovasc Surg. 1999; 47: 357\u2013361.","DOI":"10.1055\/s-2007-1013199"},{"key":"e_1_3_2_11_2","unstructured":"Lesh MD. Catheter ablation of atrial flutter and tachycardia. In: Zipes DP Jalife J eds. Cardiac Electrophysiology: From Cell to Bedside 3nd ed. Philadelphia Pa: WB Saunders; 2000:1009\u20131027."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00600-8"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.102.13.1517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T13:15:39Z","timestamp":1715519739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.102.13.1517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,26]]},"references-count":12,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2000,9,26]]}},"alternative-id":["10.1161\/01.CIR.102.13.1517"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.102.13.1517","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9,26]]},"assertion":[{"value":"2000-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}