{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:13:18Z","timestamp":1788048798306,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,10,3]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Myocardial salvage after acute myocardial infarction is defined clinically by early restoration of flow and long-term improvement in contractile function. We hypothesized that contrast-enhanced magnetic resonance imaging (MRI), performed early after myocardial infarction, indexes myocardial salvage. We studied the relationship between the transmural extent of hyperenhancement by contrast-enhanced MRI, restoration of flow, and recovery of function.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014The left anterior descending coronary artery was occluded in dogs (n=15) for either 45 minutes, 90 minutes, or permanently. Cine and contrast-enhanced MRI were performed 3 days after the procedure; cine MRI was also done 10 and 28 days after the procedure. The transmural extent of hyperenhancement and wall thickening were determined using a 60-segment model. The mean transmural extent of hyperenhancement for the 45-minute occlusion group was 22% of the 90-minute group and 18% of the permanent occlusion group (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05 for both). The transmural extent of hyperenhancement on day 3 was related to future improvement in both wall thickening score and absolute wall thickening at 10 and 28 days (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001 for each). For example, of the 415 segments on day 3 that were dysfunctional and had &lt;25% transmural hyperenhancement, 362 (87%) improved by day 28. Conversely, no segments (0 of 9) with 100% hyperenhancement improved. The transmural extent of hyperenhancement on day 3 was a better predictor of improvement in contractile function than occlusion time (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014A reduction in the transmural extent of hyperenhancement by contrast-enhanced MRI early after myocardial infarction is associated with an early restoration of flow and future improvement in contractile function.\n          <\/jats:p>","DOI":"10.1161\/01.cir.102.14.1678","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"1678-1683","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":136,"title":["Early Assessment of Myocardial Salvage by Contrast-Enhanced Magnetic Resonance Imaging"],"prefix":"10.1161","volume":"102","author":[{"given":"Hanns B.","family":"Hillenbrand","sequence":"first","affiliation":[{"name":"From the Northwestern University Medical School Feinberg Cardiovascular Research Institute (H.B.H, R.J.K., M.A.P., D.S.F., R.M.J.), Departments of Medicine (R.J.K., M.A.P., R.M.J.), and Biomedical Engineering (R.M.J.), Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Northwestern University Medical School Feinberg Cardiovascular Research Institute (H.B.H, R.J.K., M.A.P., D.S.F., R.M.J.), Departments of Medicine (R.J.K., M.A.P., R.M.J.), and Biomedical Engineering (R.M.J.), Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele A.","family":"Parker","sequence":"additional","affiliation":[{"name":"From the Northwestern University Medical School Feinberg Cardiovascular Research Institute (H.B.H, R.J.K., M.A.P., D.S.F., R.M.J.), Departments of Medicine (R.J.K., M.A.P., R.M.J.), and Biomedical Engineering (R.M.J.), Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Fieno","sequence":"additional","affiliation":[{"name":"From the Northwestern University Medical School Feinberg Cardiovascular Research Institute (H.B.H, R.J.K., M.A.P., D.S.F., R.M.J.), Departments of Medicine (R.J.K., M.A.P., R.M.J.), and Biomedical Engineering (R.M.J.), Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Judd","sequence":"additional","affiliation":[{"name":"From the Northwestern University Medical School Feinberg Cardiovascular Research Institute (H.B.H, R.J.K., M.A.P., D.S.F., R.M.J.), Departments of Medicine (R.J.K., M.A.P., R.M.J.), and Biomedical Engineering (R.M.J.), Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.53.2.6883647"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504253121701"},{"key":"e_1_3_2_3_2","first-page":"397","volume":"1","year":"1986","unstructured":"Gruppo Italiano per lo Studio della Streptochinasi nell\u2019Infarto Miocardico (GISSI). 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