{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:19:02Z","timestamp":1792016342606,"version":"4.4.0"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,10,24]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Inflammation may be involved in the origin of transplant coronary artery disease. We hypothesized that plasma levels of C-reactive protein (CRP) and interleukin-6 (IL-6), markers for systemic inflammation, would correlate with cardiac transplant graft survival.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014We studied 99 consecutive cardiac transplant recipients who were referred for routine endomyocardial biopsy and\/or surveillance coronary angiography. Plasma levels of CRP and IL-6 were measured by their respective ELISAs. Patients were divided into 2 groups: those who died or required retransplantation and those who survived without the need for retransplantation. During the follow-up period of 5.0\u00b12.7 years (range, 0.2 to 15.1 years) after transplant, 20 patients died and 9 required retransplantation. There was no significant difference in age, race, sex, cause of native myopathy, presence of diabetes, or use of aspirin, statins, or calcium channel blockers between the 2 groups. Although IL-6 did not relate to graft failure, CRP level was predictive of allograft failure (\n            <jats:italic>P<\/jats:italic>\n            =0.003). The risk of allograft failure increased 36% for every 2-fold increase in CRP level. Moreover, CRP levels also correlated significantly with the frequency of grade 3 rejection (\n            <jats:italic>P<\/jats:italic>\n            =0.02). In multivariate analysis, when combined with other significant predictors such as donor age and sex mismatching of the graft, CRP still significantly predicted graft failure (\n            <jats:italic>P<\/jats:italic>\n            =0.025) with a 32% increase in the risk of graft failure for every 2-fold increase in CRP level.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014These findings suggest that elevated plasma levels of CRP are associated with subsequent allograft failure in cardiac transplant recipients.\n          <\/jats:p>","DOI":"10.1161\/01.cir.102.17.2100","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"2100-2104","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":85,"title":["Elevated Levels of Plasma C-Reactive Protein Are Associated With Decreased Graft Survival in Cardiac Transplant Recipients"],"prefix":"10.1161","volume":"102","author":[{"given":"Marc S.","family":"Eisenberg","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Warshofsky","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Sciacca","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hal S.","family":"Wasserman","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Schwartz","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LeRoy E.","family":"Rabbani","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/362801a0"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.91.11.2844"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.1.96"},{"key":"e_1_3_2_4_2","first-page":"391","volume":"46","year":"1998","unstructured":"Ridker PM, Haughie P. 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