{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T08:09:54Z","timestamp":1794211794769,"version":"4.8.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,8,22]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Plasma brain natriuretic peptide (BNP) level increases in proportion to the degree of right ventricular dysfunction in pulmonary hypertension. We sought to assess the prognostic significance of plasma BNP in patients with primary pulmonary hypertension (PPH).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014Plasma BNP was measured in 60 patients with PPH at diagnostic catheterization, together with atrial natriuretic peptide, norepinephrine, and epinephrine. Measurements were repeated in 53 patients after a mean follow-up period of 3 months. Forty-nine of the patients received intravenous or oral prostacyclin. During a mean follow-up period of 24 months, 18 patients died of cardiopulmonary causes. According to multivariate analysis, baseline plasma BNP was an independent predictor of mortality. Patients with a supramedian level of baseline BNP (\u2265150 pg\/mL) had a significantly lower survival rate than those with an inframedian level, according to Kaplan-Meier survival curves (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). Plasma BNP in survivors decreased significantly during the follow-up (217\u00b138 to 149\u00b130 pg\/mL,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05), whereas that in nonsurvivors increased (365\u00b177 to 544\u00b168 pg\/mL,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). Thus, survival was strikingly worse for patients with a supramedian value of follow-up BNP (\u2265180 pg\/mL) than for those with an inframedian value (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014A high level of plasma BNP, and in particular, a further increase in plasma BNP during follow-up, may have a strong, independent association with increased mortality rates in patients with PPH.\n          <\/jats:p>","DOI":"10.1161\/01.cir.102.8.865","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"865-870","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":660,"title":["Plasma Brain Natriuretic Peptide as a Prognostic Indicator in Patients With Primary Pulmonary Hypertension"],"prefix":"10.1161","volume":"102","author":[{"given":"Noritoshi","family":"Nagaya","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, National Cardiovascular Center (N. Nagaya, T.S., S.K., F.S., M.K., K.F., Y.O., N. Nakanishi, K.M.), and Research Institute, National Cardiovascular Center Research Institute (T.N., M.U., K.K.), Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Nishikimi","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, National Cardiovascular Center (N. Nagaya, T.S., S.K., F.S., M.K., K.F., Y.O., N. Nakanishi, K.M.), and Research Institute, National Cardiovascular Center Research Institute (T.N., M.U., K.K.), Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Uematsu","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, National Cardiovascular Center (N. Nagaya, T.S., S.K., F.S., M.K., K.F., Y.O., N. Nakanishi, K.M.), and Research Institute, National Cardiovascular Center Research Institute (T.N., M.U., K.K.), Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Satoh","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, National Cardiovascular Center (N. Nagaya, T.S., S.K., F.S., M.K., K.F., Y.O., N. Nakanishi, K.M.), and Research Institute, National Cardiovascular Center Research Institute (T.N., M.U., K.K.), Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Kyotani","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, National Cardiovascular Center (N. Nagaya, T.S., S.K., F.S., M.K., K.F., Y.O., N. Nakanishi, K.M.), and Research Institute, National Cardiovascular Center Research Institute (T.N., M.U., K.K.), Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Sakamaki","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, National Cardiovascular Center (N. Nagaya, T.S., S.K., F.S., M.K., K.F., Y.O., N. Nakanishi, K.M.), and Research Institute, National Cardiovascular Center Research Institute (T.N., M.U., K.K.), Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Kakishita","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, National Cardiovascular Center (N. Nagaya, T.S., S.K., F.S., M.K., K.F., Y.O., N. Nakanishi, K.M.), and Research Institute, National Cardiovascular Center Research Institute (T.N., M.U., K.K.), Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Fukushima","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, National Cardiovascular Center (N. Nagaya, T.S., S.K., F.S., M.K., K.F., Y.O., N. Nakanishi, K.M.), and Research Institute, National Cardiovascular Center Research Institute (T.N., M.U., K.K.), Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Okano","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, National Cardiovascular Center (N. Nagaya, T.S., S.K., F.S., M.K., K.F., Y.O., N. Nakanishi, K.M.), and Research Institute, National Cardiovascular Center Research Institute (T.N., M.U., K.K.), Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, National Cardiovascular Center (N. Nagaya, T.S., S.K., F.S., M.K., K.F., Y.O., N. Nakanishi, K.M.), and Research Institute, National Cardiovascular Center Research Institute (T.N., M.U., K.K.), Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Miyatake","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, National Cardiovascular Center (N. Nagaya, T.S., S.K., F.S., M.K., K.F., Y.O., N. 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