{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:00:26Z","timestamp":1789189226600,"version":"build-2803163510"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,1,2]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014The transition from compensated left ventricular hypertrophy (LVH) to heart failure is associated with alterations in the myocardial interstitium. We hypothesized that LV dilatation is associated with modifications in collagen cross-linking.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014We studied 2 rat models of LV dilatation: (1) pressure-overload hypertrophy with heart failure (POH-F) induced by suprarenal abdominal aortic banding and (2) LVH induced by 7 months of isoproterenol (ISO, 0.04 mg \u00b7 kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 d\n            <jats:sup>\u22121<\/jats:sup>\n            ) administration. In POH-F rats and in rats receiving ISO, LV dilatation and a reduced systolic chamber performance were noted. Myocardial hydroxyproline concentrations ([HPRO]) were increased in the POH-F rats, whereas in rats receiving ISO, [HPRO] was decreased. In POH-F rats, the ratio of myocardial collagen type I to type III was increased, but in rats receiving ISO, myocardial collagen I\/III was unchanged. In contrast to the diverse changes in myocardial collagen concentrations and phenotypes observed in the 2 models of LV dilatation, the ratio of myocardial insoluble to soluble (relationship between cross-linked and non\u2013cross-linked) collagen was decreased in both the POH-F and ISO groups. Moreover, administration of captopril (0.22 mmol \u00b7 kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 d\n            <jats:sup>\u22121<\/jats:sup>\n            ), which inhibited the ISO-induced reduction in myocardial insoluble\/soluble collagen but not the reduction in [HPRO], prevented the ISO-induced alterations in LV dimensions and performance.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Because decreases in the ratio of myocardial insoluble to soluble collagen parallel LV dilatation in rats, reductions in myocardial collagen cross-linking may be an important mechanism contributing to LV dilatation in heart disease.\n          <\/jats:p>","DOI":"10.1161\/01.cir.103.1.155","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:09:32Z","timestamp":1339459772000},"page":"155-160","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":146,"title":["Reduction in Myocardial Collagen Cross-Linking Parallels Left Ventricular Dilatation in Rat Models of Systolic Chamber Dysfunction"],"prefix":"10.1161","volume":"103","author":[{"given":"A. J.","family":"Woodiwiss","sequence":"first","affiliation":[{"name":"From the Laboratory of Cardiovascular Pathophysiology, Department of Physiology, University of the Witwatersrand, Johannesburg (A.J.W., O.J.T., S.S., G.R.N.), and the Departments of Anatomical Pathology and Physiology, Medical University of South Africa, Pretoria (O.J.T., E.J.L.), South Africa; and the Department of Medicine, University of Massachusetts, Worcester (T.M., E.S.C., T.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. J.","family":"Tsotetsi","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cardiovascular Pathophysiology, Department of Physiology, University of the Witwatersrand, Johannesburg (A.J.W., O.J.T., S.S., G.R.N.), and the Departments of Anatomical Pathology and Physiology, Medical University of South Africa, Pretoria (O.J.T., E.J.L.), South Africa; and the Department of Medicine, University of Massachusetts, Worcester (T.M., E.S.C., T.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sprott","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cardiovascular Pathophysiology, Department of Physiology, University of the Witwatersrand, Johannesburg (A.J.W., O.J.T., S.S., G.R.N.), and the Departments of Anatomical Pathology and Physiology, Medical University of South Africa, Pretoria (O.J.T., E.J.L.), South Africa; and the Department of Medicine, University of Massachusetts, Worcester (T.M., E.S.C., T.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Lancaster","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cardiovascular Pathophysiology, Department of Physiology, University of the Witwatersrand, Johannesburg (A.J.W., O.J.T., S.S., G.R.N.), and the Departments of Anatomical Pathology and Physiology, Medical University of South Africa, Pretoria (O.J.T., E.J.L.), South Africa; and the Department of Medicine, University of Massachusetts, Worcester (T.M., E.S.C., T.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Mela","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cardiovascular Pathophysiology, Department of Physiology, University of the Witwatersrand, Johannesburg (A.J.W., O.J.T., S.S., G.R.N.), and the Departments of Anatomical Pathology and Physiology, Medical University of South Africa, Pretoria (O.J.T., E.J.L.), South Africa; and the Department of Medicine, University of Massachusetts, Worcester (T.M., E.S.C., T.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. S.","family":"Chung","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cardiovascular Pathophysiology, Department of Physiology, University of the Witwatersrand, Johannesburg (A.J.W., O.J.T., S.S., G.R.N.), and the Departments of Anatomical Pathology and Physiology, Medical University of South Africa, Pretoria (O.J.T., E.J.L.), South Africa; and the Department of Medicine, University of Massachusetts, Worcester (T.M., E.S.C., T.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. E.","family":"Meyer","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cardiovascular Pathophysiology, Department of Physiology, University of the Witwatersrand, Johannesburg (A.J.W., O.J.T., S.S., G.R.N.), and the Departments of Anatomical Pathology and Physiology, Medical University of South Africa, Pretoria (O.J.T., E.J.L.), South Africa; and the Department of Medicine, University of Massachusetts, Worcester (T.M., E.S.C., T.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. R.","family":"Norton","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cardiovascular Pathophysiology, Department of Physiology, University of the Witwatersrand, Johannesburg (A.J.W., O.J.T., S.S., G.R.N.), and the Departments of Anatomical Pathology and Physiology, Medical University of South Africa, Pretoria (O.J.T., E.J.L.), South Africa; and the Department of Medicine, University of Massachusetts, Worcester (T.M., E.S.C., T.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00474-5"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115787"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.75.1.8013068"},{"key":"e_1_3_2_4_2","first-page":"H308","volume":"261","year":"1991","unstructured":"Spinale FG, Tomita M, Zellner JL, et al. 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