{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:30:20Z","timestamp":1775277020312,"version":"3.50.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,4,10]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Peripheral arterial disease (PAD) is a severe atherosclerotic condition frequently accompanied by inflammation and oxidative stress. We hypothesized that vitamin C antioxidant levels might be low in PAD and are related to inflammation and disease severity.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014We investigated vitamin C (\n            <jats:sc>l<\/jats:sc>\n            -ascorbic acid) levels in 85 PAD patients, 106 hypertensives without PAD, and 113 healthy subjects. Serum\n            <jats:sc>l<\/jats:sc>\n            -ascorbic acid concentrations were low among PAD patients (median, 27.8 \u03bcmol\/L) despite comparable smoking status and dietary intake with the other groups (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). Subclinical vitamin C deficiency (&lt;11.4 \u03bcmol\/L), confirmed by low serum alkaline phosphatase activity, was found in 14% of the PAD patients but not in the other groups. Serum C-reactive protein (CRP) concentrations were significantly higher in PAD patients (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001) and negatively correlated with\n            <jats:sc>l<\/jats:sc>\n            -ascorbic acid levels (\n            <jats:italic>r<\/jats:italic>\n            =\u22120.742,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). In stepwise multivariate analysis, low\n            <jats:sc>l<\/jats:sc>\n            -ascorbic acid concentration in PAD patients was associated with high CRP level (\n            <jats:italic>P<\/jats:italic>\n            =0.0001), smoking (\n            <jats:italic>P<\/jats:italic>\n            =0.0009), and shorter absolute claudication distance on a standardized graded treadmill test (\n            <jats:italic>P<\/jats:italic>\n            =0.029).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Vitamin C concentrations are lower in intermittent claudicant patients in association with higher CRP levels and severity of PAD. Future studies attempting to relate vitamin C levels to disease occurrence should include in their analysis an inflammatory marker such as CRP.\n          <\/jats:p>","DOI":"10.1161\/01.cir.103.14.1863","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:09:32Z","timestamp":1339459772000},"page":"1863-1868","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":140,"title":["Serum Vitamin C Concentration Is Low in Peripheral Arterial Disease and Is Associated With Inflammation and Severity of Atherosclerosis"],"prefix":"10.1161","volume":"103","author":[{"given":"Michel","family":"Langlois","sequence":"first","affiliation":[{"name":"From the Departments of Clinical Chemistry (M.L., J.D.) and Cardiology (D.D., M.D.B., D.L.C.), Ghent University Hospital, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Duprez","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Chemistry (M.L., J.D.) and Cardiology (D.D., M.D.B., D.L.C.), Ghent University Hospital, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris","family":"Delanghe","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Chemistry (M.L., J.D.) and Cardiology (D.D., M.D.B., D.L.C.), Ghent University Hospital, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"De Buyzere","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Chemistry (M.L., J.D.) and Cardiology (D.D., M.D.B., D.L.C.), Ghent University Hospital, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis L.","family":"Clement","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Chemistry (M.L., J.D.) and Cardiology (D.D., M.D.B., D.L.C.), Ghent University Hospital, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.71.3.3156006"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.3.614"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7070.1440"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.19.3.538"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.1394"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X9700200310"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.19.10.2355"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.5.425"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.16.6377"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115035"},{"key":"e_1_3_2_12_2","first-page":"151","volume":"17","year":"1999","unstructured":"1999 World Health Organization. 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