{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:00:04Z","timestamp":1787652004809,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,4,17]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014There is accumulating data that acute coronary syndromes relate to recent onset activation of inflammation affecting atherosclerotic plaques. Increased blood levels of oxidized low density lipoprotein (ox-LDL) could play a role in these circumstances.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014Ox-LDL levels were measured in 135 patients with acute myocardial infarction (AMI; n=45), unstable angina pectoris (UAP; n=45), and stable angina pectoris (SAP; n=45) and in 46 control subjects using a sandwich ELISA method. In addition, 33 atherectomy specimens obtained from a different cohort of patients with SAP (n=10) and UAP (n=23) were studied immunohistochemically for ox-LDL. In AMI patients, ox-LDL levels were significantly higher than in patients with UAP (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0005) or SAP (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001) or in controls (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001) (AMI, 1.95\u00b11.42 ng\/5 \u03bcg LDL protein; UAP, 1.19\u00b10.74 ng\/5 \u03bcg LDL protein; SAP, 0.89\u00b10.48 ng\/5 \u03bcg LDL protein; control, 0.58\u00b10.23 ng\/5 \u03bcg LDL protein). Serum levels of total, HDL, and LDL cholesterol did not differ among these patient groups. In the atherectomy specimens, the surface area containing ox-LDL\u2013positive macrophages was significantly higher in patients with UAP than in those with SAP (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014This study demonstrates that ox-LDL levels show a significant positive correlation with the severity of acute coronary syndromes and that the more severe lesions also contain a significantly higher percentage of ox-LDL\u2013positive macrophages. These observations suggest that increased levels of ox-LDL relate to plaque instability in human coronary atherosclerotic lesions.\n          <\/jats:p>","DOI":"10.1161\/01.cir.103.15.1955","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:09:32Z","timestamp":1339459772000},"page":"1955-1960","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":572,"title":["Elevated Levels of Oxidized Low Density Lipoprotein Show a Positive Relationship With the Severity of Acute Coronary Syndromes"],"prefix":"10.1161","volume":"103","author":[{"given":"Shoichi","family":"Ehara","sequence":"first","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Ueda","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Naruko","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Haze","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Itoh","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Otsuka","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryushi","family":"Komatsu","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Matsuo","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Itabe","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Takano","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Yoshiyama","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton E.","family":"Becker","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.E., T.N., K.H., A.I., M.O.), Osaka City General Hospital; the Department of Pathology (M.U., R.K., T.M.) and First Department of Internal Medicine (M.Y., K.T., J.Y.), Osaka City University Medical School, Osaka; the Department of Microbiology and Molecular Pathology (H.I., T.T.), Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan; and the Department of Cardiovascular Pathology (Y.T., A.E.B.), Academic Medical Center, University of Amsterdam,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07591-5"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.76.1.24"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.80.1.14"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198904063201407"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.18.1.100"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.98.15.1487"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36602-4"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37634-3"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.2.2752565"},{"key":"e_1_3_1_10_2","first-page":"154","volume":"153","year":"1992","unstructured":"The fifth report of the Joint National Committee on detection, evaluation and treatment of high blood pressure (JNC V). 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