{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:54:02Z","timestamp":1773291242588,"version":"3.50.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,5,8]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014C-reactive protein (CRP) plasma levels have been associated with short- and long-term occurrence of coronary events. We investigated whether circulating inflammatory cell responsiveness to low-grade stimuli could contribute to the reported association between CRP and coronary events.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014We studied 32 patients with unstable angina who were followed for 24 months and were free of symptoms for 6 months (group 1): 19 patients had persistently high CRP levels (&gt;0.3 mg\/dL) (group 1A); 13 patients had normal CRP levels (group 1B). During the follow-up, 12 (63%) group 1A but no group 1B patients developed an infarction or recurrence of unstable angina (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). Eighteen patients with chronic stable angina (group 2) and 18 healthy subjects (group 3) were studied as controls. Interleukin (IL)-6 production (median, range) by peripheral blood mononuclear cells after 4 hours of in vitro stimulation with 1 ng\/mL lipopolysaccharide (LPS) was significantly higher in group 1A (4526 pg\/mL, 3042 to 10 583 pg\/mL) than in group 1B (1752 pg\/mL, 75 to 3981 pg\/mL), group 2 (707 pg\/mL, 41 to 3275 pg\/mL), and group 3 (488 pg\/mL, 92 to 3503 pg\/mL) (all\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). No significant differences were observed among the other groups. IL-6 production after LPS-challenge was correlated with baseline CRP levels (\n            <jats:italic>r<\/jats:italic>\n            =0.42,\n            <jats:italic>P<\/jats:italic>\n            =0.005).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Mononuclear cells of patients with recurrent phases of instability exhibit an enhanced production of IL-6 in response to low-dose of LPS, correlated with baseline CRP levels, 6 months after the last acute event. This persisting enhanced acute-phase responsiveness may help explain the association between CRP and acute coronary events.\n          <\/jats:p>","DOI":"10.1161\/01.cir.103.18.2236","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:09:32Z","timestamp":1339459772000},"page":"2236-2241","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Enhanced Response of Blood Monocytes to In Vitro Lipopolysaccharide-Challenge in Patients With Recurrent Unstable Angina"],"prefix":"10.1161","volume":"103","author":[{"given":"Giovanna","family":"Liuzzo","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Catholic University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominick J.","family":"Angiolillo","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Catholic University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Buffon","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Catholic University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Rizzello","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Catholic University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Colizzi","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Catholic University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ginnetti","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Catholic University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi M.","family":"Biasucci","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Catholic University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attilio","family":"Maseri","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Catholic University, Rome, 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