{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T04:46:35Z","timestamp":1783226795273,"version":"3.54.6"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,5,15]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Residual reduction of relative coronary flow velocity reserve (rCVR) after successful coronary intervention has been related to microvascular impairment. However, the incidence of cardiac enzyme elevation as a surrogate marker of an underlying embolic myocardial injury in these cases has not been studied.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014A series of 55 consecutive patients with successful coronary stenting, periprocedural intracoronary Doppler analysis, and determination of creatine kinase (CK; upper limit of normal [ULN] for women 70 IU\/L, for men 80 IU\/L) and cardiac troponin T (cTnT; bedside test, threshold 0.1 ng\/mL) before and 6, 12, and 24 hours after intervention were studied. Postprocedural rCVR was the only intracoronary Doppler parameter that independently correlated with cTnT (\n            <jats:italic>r<\/jats:italic>\n            =\u22120.498,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) and CK outcome (\n            <jats:italic>r<\/jats:italic>\n            =\u22120.406,\n            <jats:italic>P<\/jats:italic>\n            =0.002). Receiver operating characteristic analysis identified a postprocedural rCVR of 0.78 as the best discriminating value, with a sensitivity of 83.3% and 69.2% and a specificity of 79.1% and 76.2% for detection of cTnT and CK elevation, respectively. Stratified according to this cutoff value, the incidence of cTnT elevation was 52.6% in patients with (n=19) and 5.6% in patients without (n=36) a postprocedural rCVR &lt;0.78 (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001), associated with a CK elevation &gt;1 times the ULN in 36.8% and 5.6% (\n            <jats:italic>P<\/jats:italic>\n            =0.005) of patients, respectively.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Cardiac marker elevation can frequently be found after coronary procedures that are associated with a persistent reduction of rCVR, indicating procedural embolization of atherothrombotic debris with microvascular impairment and myocardial injury as a potential underlying mechanism.\n          <\/jats:p>","DOI":"10.1161\/01.cir.103.19.2339","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:09:32Z","timestamp":1339459772000},"page":"2339-2345","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":101,"title":["Abnormal Coronary Flow Velocity Reserve After Coronary Intervention Is Associated With Cardiac Marker Elevation"],"prefix":"10.1161","volume":"103","author":[{"given":"Joerg","family":"Herrmann","sequence":"first","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; the Department of Cardiology (J.G.), Zhongshan Hospital, Shanghai, China; and the Division of Cardiovascular Diseases (A.L.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Haude","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; the Department of Cardiology (J.G.), Zhongshan Hospital, Shanghai, China; and the Division of Cardiovascular Diseases (A.L.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; the Department of Cardiology (J.G.), Zhongshan Hospital, Shanghai, China; and the Division of Cardiovascular Diseases (A.L.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Schulz","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; the Department of Cardiology (J.G.), Zhongshan Hospital, Shanghai, China; and the Division of Cardiovascular Diseases (A.L.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Volbracht","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; the Department of Cardiology (J.G.), Zhongshan Hospital, Shanghai, China; and the Division of Cardiovascular Diseases (A.L.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; the Department of Cardiology (J.G.), Zhongshan Hospital, Shanghai, China; and the Division of Cardiovascular Diseases (A.L.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schmermund","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; the Department of Cardiology (J.G.), Zhongshan Hospital, Shanghai, China; and the Division of Cardiovascular Diseases (A.L.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich","family":"Wieneke","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; the Department of Cardiology (J.G.), Zhongshan Hospital, Shanghai, China; and the Division of Cardiovascular Diseases (A.L.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"von Birgelen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; the Department of Cardiology (J.G.), Zhongshan Hospital, Shanghai, China; and the Division of Cardiovascular Diseases (A.L.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Eggebrecht","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; the Department of Cardiology (J.G.), Zhongshan Hospital, Shanghai, China; and the Division of Cardiovascular Diseases (A.L.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"Baumgart","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; the Department of Cardiology (J.G.), Zhongshan Hospital, Shanghai, China; and the Division of Cardiovascular Diseases (A.L.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Heusch","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; the Department of Cardiology (J.G.), Zhongshan Hospital, Shanghai, China; and the Division of Cardiovascular Diseases (A.L.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimund","family":"Erbel","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (J.H., M.H., A.S., H.W., C.v.B., H.E., D.B., R.E.), the Department of Clinical Chemistry (L.V.), and the Department of Pathophysiology (R.S., G.H.), University Clinic Essen, Essen, Germany; 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