{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:48:43Z","timestamp":1791046123220,"version":"4.1.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,6,5]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Controversy continues as to whether adenosine or dobutamine is the superior pharmacological stress agent for myocardial contrast echocardiography (MCE).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014We compared real-time MCE refilling curves and wall thickening during adenosine and dobutamine stress in 14 open-chest dogs with left anterior descending and left circumflex coronary artery stenoses that reduced hyperemia by 40% to 60% and 70% to 90% (mild and severe non\u2013flow-limiting stenosis, NFLS) and resting flow by 10% to 30% and 35% to 50% (mild and severe flow-limiting stenosis, FLS). MCE was performed with low-energy imaging during Optison infusion. After high-energy bubble destruction, time-intensity data from risk beds were fitted for an exponential function as\n            <jats:italic>y<\/jats:italic>\n            =A(1\u2212\n            <jats:italic>e<\/jats:italic>\n            <jats:sup>\u2212<\/jats:sup>\n            <jats:sup>bt<\/jats:sup>\n            ), from which the rate of intensity increase (b) and maximal plateau intensity (A) were derived. Although severe NFLS and greater stenoses decreased b with both dobutamine and adenosine, with mild NFLS it was reduced in 58% of animals with dobutamine versus 8% with adenosine. The absolute decrease in b, however, was greater for adenosine than dobutamine with FLS. The A parameter was decreased with both adenosine and dobutamine only with the most severe FLS. Wall thickening was decreased with dobutamine in 33% of animals with severe NFLS and in all animals with any FLS; with adenosine, in all with severe FLS.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Both dobutamine and adenosine significantly reduce MCE refilling rates in the setting of severe stenosis and in the absence of contractile abnormalities. Dobutamine decreases refilling rate and wall thickening at a less reduced flow grade than adenosine, but adenosine produces a greater magnitude of change than dobutamine.\n          <\/jats:p>","DOI":"10.1161\/01.cir.103.22.2724","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:09:32Z","timestamp":1339459772000},"page":"2724-2730","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Comparative Value of Dobutamine and Adenosine Stress in the Detection of Coronary Stenosis With Myocardial Contrast Echocardiography"],"prefix":"10.1161","volume":"103","author":[{"given":"Ste\u0301phane","family":"Lafitte","sequence":"first","affiliation":[{"name":"From the Cardiovascular Division, University of California at San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Matsugata","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Division, University of California at San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Peters","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Division, University of California at San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Togni","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Division, University of California at San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monet","family":"Strachan","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Division, University of California at San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oi Ling","family":"Kwan","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Division, University of California at San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony N.","family":"DeMaria","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Division, University of California at San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"456","volume":"35","year":"2000","unstructured":"Porter T, Xie F, Oster R, et al. Real-time myocardial perfusion in humans using low mechanical index PPI and intravenous optison during dobutamine stress echocardiography. J Am Coll Cardiol. 2000;35:456.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(97)70027-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.5.473"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.6.H2363"},{"key":"e_1_3_2_5_2","first-page":"372","volume":"46","year":"1999","unstructured":"Simpson D, Chin C, Burns P. Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents. 1999 IEEE-TUFF Control. 1999;46:372\u2013382.","journal-title":"1999 IEEE-TUFF Control"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.76.4.3652428"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.2.8425283"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(96)90468-X"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.57.6.416923"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.10.3346"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00319-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00478-5"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.7.2353"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.103.22.2724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T12:58:13Z","timestamp":1715518693000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.103.22.2724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,5]]},"references-count":13,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2001,6,5]]}},"alternative-id":["10.1161\/01.CIR.103.22.2724"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.103.22.2724","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6,5]]},"assertion":[{"value":"2000-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-06-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}