{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T22:45:27Z","timestamp":1759099527962},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,6,19]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014This study evaluates the role of RR interval distribution pattern as an outcome predictor of radiofrequency (RF) modification of atrioventricular (AV) node in chronic atrial fibrillation (AF) and attempts to elucidate the likely mechanism of rate control.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014Sixty-five patients with chronic AF underwent AV node modification. The RR interval distribution pattern was derived from 24-hour ECG recordings obtained before and after the procedure. The preablation pattern was bimodal (B) in 36 patients (55%) and unimodal (U) in 29 patients (45%). After the modification procedure, the B pattern shifted to U (78%) or became modified B (22%). The mean number of RF pulses delivered and the fluoroscopy time were n=8\u00b15 and 24\u00b111 minutes, respectively, in patients with B pattern versus n=18\u00b17 and 45\u00b117 minutes in patients with U pattern (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001 for both). The location of successful ablation was posteroseptal and lower midseptal in 26 patients (81%) with B pattern versus 2 (13%) with U pattern (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). Mean and maximal ventricular rates and heart rate at peak exercise were reduced after the procedure in both groups (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001 for all). Long-term success rate, AV block incidence, and pacemaker implantation rate were 89%, 0%, and 8%, respectively, in patients with B pattern versus 52% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001), 21% (\n            <jats:italic>P<\/jats:italic>\n            =0.006), and 48% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) in patients with U pattern.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014RF modification of the AV node is expected to be more effective, safe, and expeditious in patients with chronic AF and B RR interval distribution pattern. Posterior atrionodal input ablation may be the prevailing mechanism of rate control in these patients, whereas U-pattern patients may benefit from partial injury to the AV node.\n          <\/jats:p>","DOI":"10.1161\/01.cir.103.24.2942","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:09:32Z","timestamp":1339459772000},"page":"2942-2948","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Atrioventricular Node Modification in Patients With Chronic Atrial Fibrillation"],"prefix":"10.1161","volume":"103","author":[{"given":"Stelios","family":"Rokas","sequence":"first","affiliation":[{"name":"From the Interventional Cardiology Unit, Department of Clinical Therapeutics, Alexandra Hospital, Athens University Medical School, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Styliani","family":"Gaitanidou","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Department of Clinical Therapeutics, Alexandra Hospital, Athens University Medical School, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Chatzidou","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Department of Clinical Therapeutics, Alexandra Hospital, Athens University Medical School, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costas","family":"Pamboucas","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Department of Clinical Therapeutics, Alexandra Hospital, Athens University Medical School, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Achtipis","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Department of Clinical Therapeutics, Alexandra Hospital, Athens University Medical School, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stamatios","family":"Stamatelopoulos","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Department of Clinical Therapeutics, Alexandra Hospital, Athens University Medical School, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.5.7955187"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410063311404"},{"key":"e_1_3_1_3_2","first-page":"113","volume":"27","year":"1997","unstructured":"Morady F, Hasse C, Strickberger S, et al. Long-term follow-up after radiofrequency modification of the atrioventricular node in patients with atrial fibrillation. J Am Coll Cardiol. 1997;27:113\u2013121.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.41.5.783"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a062070"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/21.6.455"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00593-7"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1995.tb00772.x"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.93.9.1690"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.10.3477"},{"key":"e_1_3_1_11_2","first-page":"H2333","volume":"267","year":"1994","unstructured":"Stein K, Lerman B. Evidence for functionally distinct dual atrial inputs to the human AV node. Am J Physiol. 1994;267:H2333\u2013H2341.","journal-title":"Am J Physiol"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.11.2856"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.93.2.277"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00315-H"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00206-8"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1995.tb00447.x"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.91.4.1086"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207303270504"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.5.8491010"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.2.188"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.103.24.2942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T13:16:40Z","timestamp":1715519800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.103.24.2942"}},"subtitle":["Role of Morphology of RR Interval Variation"],"short-title":[],"issued":{"date-parts":[[2001,6,19]]},"references-count":20,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2001,6,19]]}},"alternative-id":["10.1161\/01.CIR.103.24.2942"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.103.24.2942","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"type":"print","value":"0009-7322"},{"type":"electronic","value":"1524-4539"}],"subject":[],"published":{"date-parts":[[2001,6,19]]},"assertion":[{"value":"2000-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}