{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:53:11Z","timestamp":1787017991213,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,6,19]]},"abstract":"\n Background<\/jats:italic>\n \u2014Common carotid artery intima-media thickness (IMT) progression was compared between 4 years of treatment with nifedipine and diuretic.\n <\/jats:p>\n \n Methods and Results<\/jats:italic>\n \u2014This study, ancillary to the International Nifedipine GITS Study: Intervention as a Goal in Hypertension Treatment (INSIGHT), involved nifedipine 30 mg or co-amilozide (hydrochlorothiazide 25 mg and amiloride 2.5 mg) with optional subsequent titration. Among 439 randomized hypertensive patients, 324 had \u22651 year of follow-up (intent-to-treat group), and 242 completed follow-up (until-end-of-study group). Ultrasonography was performed at baseline, 4 months later, and then every year. Central computerized reading provided far-wall IMT, diameter, and cross-sectional area IMT (CSA-IMT). The primary outcome was IMT progression rate (slope of IMT-time regression). Secondary outcomes were changes from baseline (\u0394) in IMT, diameter, and CSA-IMT. In the until-end-of-study population, between-treatment differences existed in IMT progression rate (\n P<\/jats:italic>\n =0.002), \u0394 IMT (\n P<\/jats:italic>\n =0.001), and \u0394 CSA-IMT (\n P<\/jats:italic>\n =0.006), because IMT progressed on co-amilozide but not on nifedipine. In the intent-to-treat population, treatment differences existed in \u0394 IMT (\n P<\/jats:italic>\n =0.004) and \u0394 CSA-IMT (\n P<\/jats:italic>\n =0.04) but not in IMT progression rate (\n P<\/jats:italic>\n =0.09). Patients with \u22652, 3, or 4 years of follow-up showed treatment differences in IMT progression rate (\n P<\/jats:italic>\n =0.04, 0.004, 0.007, respectively), \u0394 IMT (\n P<\/jats:italic>\n =0.005, 0.001, 0.005), and \u0394 CSA-IMT (\n P<\/jats:italic>\n =0.025, 0.013, 0.015). Diameter decreased more on co-amilozide than on nifedipine in the intent-to-treat population (\n P<\/jats:italic>\n <0.05), whereas blood pressure decreased similarly on both treatments.\n <\/jats:p>\n \n Conclusions<\/jats:italic>\n \u2014A difference in early carotid wall changes is shown between 2 equally effective antihypertensive treatments.\n <\/jats:p>","DOI":"10.1161\/01.cir.103.24.2949","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T20:09:32Z","timestamp":1339445372000},"page":"2949-2954","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":132,"title":["Differential Effects of Nifedipine and Co-Amilozide on the Progression of Early Carotid Wall Changes"],"prefix":"10.1161","volume":"103","author":[{"given":"Alain","family":"Simon","sequence":"first","affiliation":[{"name":"From the Centre de Me\u0301decine Pre\u0301ventive Cardiovasculaire, Ho\u0302pital Broussais, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je\u0301rome","family":"Garie\u0301py","sequence":"additional","affiliation":[{"name":"From the Centre de Me\u0301decine Pre\u0301ventive Cardiovasculaire, Ho\u0302pital Broussais, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Moyse","sequence":"additional","affiliation":[{"name":"From the Centre de Me\u0301decine Pre\u0301ventive Cardiovasculaire, Ho\u0302pital Broussais, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Levenson","sequence":"additional","affiliation":[{"name":"From the Centre de Me\u0301decine Pre\u0301ventive Cardiovasculaire, Ho\u0302pital Broussais, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.15.6.666"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.22.1.111"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.31.1.534"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00440160095012"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)90186-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(99)00089-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2977(99)00053-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.34.1.51"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540100029024"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816110-00014"},{"key":"e_1_3_2_11_2","first-page":"S27","volume":"28","year":"1996","unstructured":"Simon A, Gariepy J, Provost JC, et al. Nifedipine, hypertension, and arterial wall thickness in extracoronary arteries: design features of a clinical trial using non invasive ultrasound end points. J Cardiovasc Pharmacol. 1996;28:S27\u2013S32.","journal-title":"J Cardiovasc Pharmacol"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02527-7"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.6.1414"},{"key":"e_1_3_2_14_2","first-page":"127","volume":"15","year":"1996","unstructured":"Linhart A, Gariepy J, Giral P, et al. Carotid artery and left ventricular structural relationship in asymptomatic men at risk for cardiovascular disease. Atherosclerosis. 1996;15:127:103\u2013112.","journal-title":"Atherosclerosis"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816070-00008"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-4-199802150-00002"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/4.7.512S"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","unstructured":"Levenson JA Safar ME Simon AC et al. Systemic and arterial hemodynamic effects of nifedipine (20 mg) in mild-to-moderate hypertension. Hypertension. 1983;5(suppl V):V-57\u2013V-60.","DOI":"10.1161\/01.HYP.5.6_Pt_3.V57"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.103.24.2949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T09:16:56Z","timestamp":1715505416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.103.24.2949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,19]]},"references-count":18,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2001,6,19]]}},"alternative-id":["10.1161\/01.CIR.103.24.2949"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.103.24.2949","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6,19]]},"assertion":[{"value":"2001-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}