{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:56:03Z","timestamp":1787932563428,"version":"build-2784847793"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1965,4]]},"abstract":"<jats:p>Lesions causing obstruction to the outflow of blood from the left ventricle may reside in the ascending aorta, the aortic valve, or the outflow tract of the left ventricle.<\/jats:p>\n          <jats:p>Conditions involving the ascending aorta are usually congenital, and designated as supravalvular aortic stenosis. A tendency is present for this condition to be associated with mental retardation, stenosis of peripheral pulmonary arteries, stenosis of branches of the aortic arch, and a peculiar facies. Secondary narrowing of coronary arteries may occur.<\/jats:p>\n          <jats:p>Obstruction at the aortic valve is usually represented by a stenotic lesion. In some instances, the basis for stenosis is congenital; in others, it is acquired either through the direct effects of rheumatic endocarditis or through calcification of an acquired or congenital bicuspid aortic valve.<\/jats:p>\n          <jats:p>Atresia of the aortic valve causes death in infancy.<\/jats:p>\n          <jats:p>Subaortic stenosis is a complicated subject. It may be represented by a primary anomaly of the left ventricular outflow tract or may be secondary either to conditions primary in the mitral valve or to generalized diseases of the myocardium.<\/jats:p>\n          <jats:p>In some instances of subaortic stenosis, this process is one part of a complex cardiac malformation.<\/jats:p>","DOI":"10.1161\/01.cir.31.4.586","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:27:25Z","timestamp":1339457245000},"page":"586-599","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":125,"title":["Pathology of Left Ventricular Outflow Tract Obstruction"],"prefix":"10.1161","volume":"31","author":[{"given":"JESSE E.","family":"EDWARDS","sequence":"first","affiliation":[{"name":"From the Departments of Pathology, University of Minnesota School of Medicine, Minneapolis, and The Charles T. Miller Hospital, St. Paul, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.31.4.586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T14:13:48Z","timestamp":1715523228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.31.4.586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1965,4]]}},"alternative-id":["10.1161\/01.CIR.31.4.586"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.31.4.586","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1965,4]]},"assertion":[{"value":"1965-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}