{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:12:44Z","timestamp":1756995164094},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1966,3]]},"abstract":"<jats:p>Cardiac catheterization and phonocardiography data were obtained from patients with mitral stenosis at rest and during exercise. There was a linear relationship between the percentage decrease of the interval from closure of the aortic valve to the mitral valve opening snap (A2-OS) and the percentage increase [see figure in the PDF file] of the left atrial mean pressure from rest to exercise. The duration of the A2-OS interval was an effective indicator of the level of the left atrial mean pressure during exercise. The duration of the A2-OS interval during exercise allowed separation of patients with mild stenosis from those with moderate or severe stenosis but could not be used to distinguish moderate stenosis from severe stenosis.<\/jats:p>","DOI":"10.1161\/01.cir.33.3.399","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:27:25Z","timestamp":1339457245000},"page":"399-403","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["The Second Sound-Mitral Opening Snap (A2-OS) Interval during Exercise in the Evaluation of Mitral Stenosis"],"prefix":"10.1161","volume":"33","author":[{"given":"ABNER J.","family":"DELMAN","sequence":"first","affiliation":[{"name":"From the Phonocardiography and Cardiac Catheterization Laboratories, Cardiology Service, Medical Division, Montefiore Hospital and Medical Center, Bronx, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GARET M.","family":"GORDON","sequence":"additional","affiliation":[{"name":"From the Phonocardiography and Cardiac Catheterization Laboratories, Cardiology Service, Medical Division, Montefiore Hospital and Medical Center, Bronx, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMANUEL","family":"STEIN","sequence":"additional","affiliation":[{"name":"From the Phonocardiography and Cardiac Catheterization Laboratories, Cardiology Service, Medical Division, Montefiore Hospital and Medical Center, Bronx, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DORIS J. W.","family":"ESCHER","sequence":"additional","affiliation":[{"name":"From the Phonocardiography and Cardiac Catheterization Laboratories, Cardiology Service, Medical Division, Montefiore Hospital and Medical Center, Bronx, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.33.3.399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T13:57:11Z","timestamp":1715522231000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.33.3.399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1966,3]]}},"alternative-id":["10.1161\/01.CIR.33.3.399"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.33.3.399","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,3]]},"assertion":[{"value":"1966-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}