{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:30:20Z","timestamp":1789702220417,"version":"4.0.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1968,7]]},"abstract":"<jats:p>In 20 patients studied by cardiac catheterization, the time required for the diastolic left atrioventricular pressure difference to fall to half its initial value (half-time) varied with the anatomic severity of the valvular stenosis. In mild mitral stenosis, the half-time was approximately 100 msec; in moderate stenosis, it was about 200 msec; and it was 300 msec or longer in severe stenosis. The half-time at the nonstenotic mitral valve was less than 25 msec.<\/jats:p>\n          <jats:p>Although exercise increased the atrioventricular pressure gradient, heart rate, and cardiac output significantly, the half-time was affected only slightly. Mitral regurgitation of various severities did not affect the half-time. The half-time appears to vary inversely with the anatomic orifice area of the mitral valve. The determination of the half-time obviates the need for the commonly used exercise test for the evaluation of mitral stenosis.<\/jats:p>","DOI":"10.1161\/01.cir.38.1.144","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:27:25Z","timestamp":1339457245000},"page":"144-150","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":92,"title":["Atrioventricular Pressure Half-Time"],"prefix":"10.1161","volume":"38","author":[{"given":"ALBERT J.","family":"LIBANOFF","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Division of Medicine, City of Hope Medical Center, Duarte, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SIMON","family":"RODBARD","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Division of Medicine, City of Hope Medical Center, Duarte, California."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.38.1.144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T14:02:08Z","timestamp":1715522528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.38.1.144"}},"subtitle":["Measure of Mitral Valve Orifice Area"],"short-title":[],"issued":{"date-parts":[[1968,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1968,7]]}},"alternative-id":["10.1161\/01.CIR.38.1.144"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.38.1.144","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,7]]},"assertion":[{"value":"1968-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}