{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:18:46Z","timestamp":1792030726959,"version":"4.4.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1969,10]]},"abstract":"<jats:p>Clinical, pharmacologic, and pathologic findings presented are those in a 12-year-old boy with primary pulmonary hypertension associated with medial hypertrophy of the pulmonary muscular arteries and arterioles.<\/jats:p>\n          <jats:p>Intrapulmonary arterial administration of acetylcholine, tolazoline (Priscoline), or isoproterenol resulted in a fall in pulmonary vascular resistance and pressure.<\/jats:p>\n          <jats:p>Perforation of the right ventricle by an indwelling catheter terminated studies on the results of long-term intrapulmonary arterial administration of drugs shown to be effective.<\/jats:p>","DOI":"10.1161\/01.cir.40.4.583","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:27:25Z","timestamp":1339457245000},"page":"583-588","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Primary Pulmonary Hypertension in a Child"],"prefix":"10.1161","volume":"40","author":[{"given":"B. N. SATYANARAYANA","family":"RAO","sequence":"first","affiliation":[{"name":"From the Department of Pathology, the Charles T. Miller Hospital, St. Paul, Minnesota, and the Departments of Pediatrics and Pathology, University of Minnesota, Minneapolis, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAMES H.","family":"MOLLER","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, the Charles T. Miller Hospital, St. Paul, Minnesota, and the Departments of Pediatrics and Pathology, University of Minnesota, Minneapolis, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JESSE E.","family":"EDWARDS","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, the Charles T. Miller Hospital, St. Paul, Minnesota, and the Departments of Pediatrics and Pathology, University of Minnesota, Minneapolis, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.40.4.583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T14:10:12Z","timestamp":1715523012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.40.4.583"}},"subtitle":["Response to Pharmacologic Agents"],"short-title":[],"issued":{"date-parts":[[1969,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1969,10]]}},"alternative-id":["10.1161\/01.CIR.40.4.583"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.40.4.583","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,10]]},"assertion":[{"value":"1969-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}