{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:39:29Z","timestamp":1788406769679,"version":"build-2803163510"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1971,2]]},"abstract":"<jats:p>\n            Factors that regulate the arterial level of lidocaine during a constant infusion were investigated in 17 patients undergoing cardiac catheterization. Lidocaine was administered by a 50 mg bolus, followed by a constant infusion of 40 \u00b5g\/kg\/min until steady state conditions were achieved. Cardiac output and estimated hepatic blood flow were also determined. An inverse relationship between arterial lidocaine levels and cardiac index was observed. With a low cardiac index of 1.9 \u00b1 0.3 liters\/min\/m\n            <jats:sup>2<\/jats:sup>\n            the arterial level was 2.4 (\u00b10.4\n            <jats:sc>sem<\/jats:sc>\n            ) \u00b5g\/ml, while with a normal cardiac index of 3.3 \u00b1 0.8 liters\/min\/m\n            <jats:sup>2<\/jats:sup>\n            it was 1.5 (\u00b10.2\n            <jats:sc>sem<\/jats:sc>\n            ) \u00b5\/ml.\n          <\/jats:p>\n          <jats:p>\n            A linear relationship was also observed between estimated hepatic blood flow and cardiac index. Therefore, an inverse relationship between arterial lidocaine levels and estimated hepatic blood flow was noted. At steady-state conditions, the liver accounted for 70% (\u00b116%\n            <jats:sc>sem<\/jats:sc>\n            ) of the metabolism or removal of the lidocaine administered. These studies suggest that the administration of smaller doses of lidocaine will produce effective therapeutic levels when reduced hepatic blood flow exists.\n          <\/jats:p>","DOI":"10.1161\/01.cir.43.2.205","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:56:43Z","timestamp":1339459003000},"page":"205-211","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":207,"title":["Interrelationships of Hepatic Blood Flow, Cardiac Output, and Blood Levels of Lidocaine in Man"],"prefix":"10.1161","volume":"43","author":[{"given":"ROBERT E.","family":"STENSON","sequence":"first","affiliation":[{"name":"From the Cardiology Division, Stanford University School of Medicine, Palo Alto, Calfornia 94305."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROBERT T.","family":"CONSTANTINO","sequence":"additional","affiliation":[{"name":"From the Cardiology Division, Stanford University School of Medicine, Palo Alto, Calfornia 94305."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DONALD C.","family":"HARRISON","sequence":"additional","affiliation":[{"name":"From the Cardiology Division, Stanford University School of Medicine, Palo Alto, Calfornia 94305."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.43.2.205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T14:09:48Z","timestamp":1715522988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.43.2.205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1971,2]]}},"alternative-id":["10.1161\/01.CIR.43.2.205"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.43.2.205","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,2]]},"assertion":[{"value":"1970-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1970-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1971-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}