{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T18:52:14Z","timestamp":1758394334989},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1971,9]]},"abstract":"<jats:p>\n            Forty-two patients with pure mitral stenosis underwent a prospective, longitudinal study with two or more cardiac catheterizations 1 to 10 years apart and without intervening surgical treatment. The majority of patients had not previously had mitral valve surgery; in 16, the period of observation followed valvotomy. Twenty-seven patients showed evidence of progressive obstruction of the mitral valve; 15 showed no change in the calculated mitral valve area. In the group of patients with\n            <jats:italic>progressive<\/jats:italic>\n            disease (stenosis or restenosis) there was a consistent clinical and hemodynamic deterioration: 25 of the 27 showed increasing disability. In the\n            <jats:italic>nonprogressive<\/jats:italic>\n            group, seven of the 15 showed increasing symptomatology, most often related to the development of atrial fibrillation and a fall in cardiac output. Possible causes for the different course of mitral stenosis in the two groups are reviewed. The probability that trauma due to altered flow patterns through a stenotic valve produces progressive stenosis is suggested.\n          <\/jats:p>","DOI":"10.1161\/01.cir.44.3.381","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:56:43Z","timestamp":1339459003000},"page":"381-389","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Longitudinal Hemodynamic and Clinical Study of Mitral Stenosis"],"prefix":"10.1161","volume":"44","author":[{"given":"ALBERT A.","family":"DUBIN","sequence":"first","affiliation":[{"name":"From the Heart Research Institute, the Institute of Medical Sciences, and the Cardiology Unit, Presbyterian Hospital, Pacific Medical Center; and the Division of Cardiology, Veterans Administration Hospital, San Francisco, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HAROLD W.","family":"MARCH","sequence":"additional","affiliation":[{"name":"From the Heart Research Institute, the Institute of Medical Sciences, and the Cardiology Unit, Presbyterian Hospital, Pacific Medical Center; and the Division of Cardiology, Veterans Administration Hospital, San Francisco, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KEITH","family":"COHN","sequence":"additional","affiliation":[{"name":"From the Heart Research Institute, the Institute of Medical Sciences, and the Cardiology Unit, Presbyterian Hospital, Pacific Medical Center; and the Division of Cardiology, Veterans Administration Hospital, San Francisco, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ARTHUR","family":"SELZER","sequence":"additional","affiliation":[{"name":"From the Heart Research Institute, the Institute of Medical Sciences, and the Cardiology Unit, Presbyterian Hospital, Pacific Medical Center; and the Division of Cardiology, Veterans Administration Hospital, San Francisco, California."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.44.3.381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T14:03:16Z","timestamp":1715522596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.44.3.381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1971,9]]}},"alternative-id":["10.1161\/01.CIR.44.3.381"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.44.3.381","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,9]]},"assertion":[{"value":"1970-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1971-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1971-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}