{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:06:37Z","timestamp":1762067197652},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1972,1]]},"abstract":"<jats:p>Myocardial electrolyte balance and hemodynamics were studied in 14 patients before and after the administration of ouabain. The drug caused a significant loss of potassium from the myocardium. This was accompanied by a significant positive inotropic response, indicated by an increase in the rate of rise of left ventricular pressure and systolic ejection-rate index. Heart rate, cardiac output, left ventricular end-diastolic pressure, brachial artery pressure, and left ventricular stroke-work index remained unchanged. These observations in man are compatible with those theories of digitalis action which associate inotropic effect with the inhibition of membrane sodium- and potassium-activated adenosine triphosphatase.<\/jats:p>","DOI":"10.1161\/01.cir.45.1.107","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:56:43Z","timestamp":1339459003000},"page":"107-113","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Ouabain on Myocardial Potassium and Sodium Balance in Man"],"prefix":"10.1161","volume":"45","author":[{"given":"F. JAMES","family":"BRENNAN","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Queen's University, and Kingston General Hospital, Kingston, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN L.","family":"MCCANS","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Queen's University, and Kingston General Hospital, Kingston, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIGUEL A.","family":"CHIONG","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Queen's University, and Kingston General Hospital, Kingston, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN O.","family":"PARKER","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Queen's University, and Kingston General Hospital, Kingston, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.45.1.107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T14:12:17Z","timestamp":1715523137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.45.1.107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1972,1]]}},"alternative-id":["10.1161\/01.CIR.45.1.107"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.45.1.107","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,1]]},"assertion":[{"value":"1971-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1971-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1972-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}