{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:44:59Z","timestamp":1761101099516},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1973,11]]},"abstract":"<jats:p>Nine patients with coupled ventricular premature depolarizations (VPDs) were treated with intravenous procaine amide to abolish the arrhythmia. The effect of procaine amide on the electrocardiogram was carefully observed. Seven patients were treated with intermittent intravenous therapy-100 mg of procaine amide was injected every five minutes-and two were treated by constant intravenous infusion-200 \u00b5g\/min\/kg body weight; blood for plasma procaine amide concentration was obtained 4.5 to 5 min after each dose. As the cumulative dose of procaine amide increased, plasma drug concentration increased and the frequency of coupled VPDs progressively decreased. Moreover, in every patient an interesting electrocardiographic phenomenon was observed: as plasma drug concentration increased, the coupling interval progressively increased until the arrhythmia was completely abolished. A hypothesis for procaine amide's antiarrhythmic action is offered based on this new observation. This hypothesis suggests that procaine amide prolongs conduction in the depressed portion of a re-entrant pathway such that conduction is further delayed and block finally occurs, thereby terminating the arrhythmia.<\/jats:p>","DOI":"10.1161\/01.cir.48.5.959","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:56:43Z","timestamp":1339459003000},"page":"959-970","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Procaine Amide Against Re-Entrant Ventricular Arrhythmias"],"prefix":"10.1161","volume":"48","author":[{"given":"ELSA-GRACE V.","family":"GIARDINA","sequence":"first","affiliation":[{"name":"From the Departments of Medicine and Pharmacology, College of Physicians and Surgeons, Columbia University, and the Cardiac Intensive Care Unit of the Presbyterian Hospital in the City of New York, New York, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"JR.","given":"J. THOMAS","family":"BIGGER","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and Pharmacology, College of Physicians and Surgeons, Columbia University, and the Cardiac Intensive Care Unit of the Presbyterian Hospital in the City of New York, New York, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.48.5.959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T14:06:24Z","timestamp":1715522784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.48.5.959"}},"subtitle":["Lengthening R-V Intervals of Coupled Ventricular Premature Depolarizations as an Insight into the Mechanism of Action of Procaine Amide"],"short-title":[],"issued":{"date-parts":[[1973,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1973,11]]}},"alternative-id":["10.1161\/01.CIR.48.5.959"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.48.5.959","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,11]]},"assertion":[{"value":"1973-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1973-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1973-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}