{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:07:55Z","timestamp":1760249275382},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1976,3]]},"abstract":"<jats:p>The goal of this study was to develop, on a rational basis, an index of the intrinsic diastolic elastic properties of the left ventricle. A relatively simple analytic model employing a thin-walled spherical geometry coupled with an approximate formulation of a two-dimensional constitutive relation, was used to examine the primary determinants of the pressure-volume relationship of the intact heart. The results permit comparison with other indices of compliance or wall stiffness. The slope of the dP\/dV vs P curve was found to be sensitive to the non-linear elastic constant K, but is also sensitive to variations in cardiac muscle volume. VdP\/dV was found to be sensitive to pressure. m = d(log P)\/d(log V) = (V\/P)(dP\/dV) is proposed as an index sensitive to K and relatively insensitive to both pressure and initial cardiac geometry. The index is compared with published studies. Using the data of Fester and Samet, mean values of the asymptotic log-log P-V slope, m, evaluated at end-diastole for normal, idiopathic hypertrophy, mild, moderate and severe coronary artery disease were 3.95 +\/- 0.60 (SEM), 5.05 +\/- 1.60, 5.24 +\/- 0.96, 8.35 +\/- 2.06, and 15.13 +\/- 3.0, respectively. At values of LVEDP less than 7 mm Hg the concept of simple distension is questioned. The advantages and limitations of this approximate index are discussed. This index seems to afford a practical measure of the elastic properties of the wall over a rather wide range of pressure, volume, wall mass and wall thickness.<\/jats:p>","DOI":"10.1161\/01.cir.53.3.443","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:57:40Z","timestamp":1339459060000},"page":"443-449","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Asymptotic slope of log pressure vs log volume as an approximate index of the diastolic elastic properties of the myocardium in man."],"prefix":"10.1161","volume":"53","author":[{"given":"J D","family":"Laird","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.53.3.443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T14:02:41Z","timestamp":1715522561000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.53.3.443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1976,3]]}},"alternative-id":["10.1161\/01.CIR.53.3.443"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.53.3.443","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,3]]},"assertion":[{"value":"1976-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}