{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:58:27Z","timestamp":1769111907440,"version":"3.49.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1977,10]]},"abstract":"<jats:p>The effect of acute alterations in coronary blood flow (CBF) on left ventricular (LV) end-diastolic wall thickness was measured by reflected ultrasound in twelve anesthetized dogs. During five minutes of coronary ligation, wall thickness decreased from a control of 9.0 +\/- 0.3 mm to 8.1 +\/- 0.3 mm (P less than 0.001); during reperfusion (reactive hyperemia), wall thickness was greater than control (10.2 +\/- 0.2 mm at one minute, P less than 0.001). Increased CBF produced by intracoronary nitroglycerin or papaverine resulted in transient increases in wall thickness from 8.9 +\/- 0.1 mm to 9.7 +\/- 0.2 at one minute (P less than 0.001) and 10.0 +\/- 0.6 mm to 11.2 +\/- 0.7 mm at one minute (P less than 0.001), respectively. The observed direct relation between CBF and wall thickness suggests a dynamic role for CBF in calculations of LV mass, diastolic wall stress, and myocardial stiffness constants.<\/jats:p>","DOI":"10.1161\/01.cir.56.4.593","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:57:40Z","timestamp":1339459060000},"page":"593-598","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":73,"title":["The effect of acute changes in coronary blood flow on left ventricular end-diastolic wall thickness. An echocardiographic study."],"prefix":"10.1161","volume":"56","author":[{"given":"W H","family":"Gaasch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S A","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.56.4.593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:04:01Z","timestamp":1715526241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.56.4.593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1977,10]]}},"alternative-id":["10.1161\/01.CIR.56.4.593"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.56.4.593","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,10]]},"assertion":[{"value":"1977-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}