{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:53:25Z","timestamp":1767707605627},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1978,9]]},"abstract":"<jats:p>Intracoronary administration of contrast materials causes myocardial depression which is related to serveral physiochemical properties of the contrast solution. The role of variations in ambient calcium ions (Ca++) in mediating this effect was evaluated in 19 anesthetized dogs. Sodium meglumine diatrizoate caused decreases in left ventricular peak systolic pressure (LVPSP),-12.6 +\/- 3.2%, and dp\/dt at a left ventricular pressure (LVP) of 40 mm Hg, -14.3 +\/- 4.1%. The total calcium (Cat) decreased from 10.2 +\/- 0.2 to 6.5 +\/- 0.2 mg%, while Ca++ decreased from 4.6 +\/- 0.1 mg% to 2.3 +\/- 0.7 mg%. In the presence of systemic hypocalcemia the myocardial depressant actions of this contrast materials were accentuated. Intracoronary administration of contrast material with added Ca++, calcium sodium meglumine metrizoate, caused no myocardial depression. Total calcium decreased only slightly (10.2 +\/- 0.2 to 9.1 +\/- 0.2 mg%), while Ca++ increased (4.8 +\/- 0.1 to 5.1 +\/- 0.2 mg%. During systemic hypocalcemia, the calcium metrizoate compound induced increases in LVPSP and dp\/dt\/LBP40. Thus, contrast materials caused myocardial depression which, at least in part, was related to reduction of ambient calcium through a dilutional and binding action. The addition of Ca++ to monomeric contrast materials reversed the myocardial depressant action and produced a transient rise in ambient Ca++.<\/jats:p>","DOI":"10.1161\/01.cir.58.3.512","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:57:40Z","timestamp":1339459060000},"page":"512-519","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["Alterations in calcium levels of coronary sinus blood during coronary arteriography in the dog."],"prefix":"10.1161","volume":"58","author":[{"given":"C B","family":"Higgins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.58.3.512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:01:23Z","timestamp":1715526083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.58.3.512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,9]]}},"alternative-id":["10.1161\/01.CIR.58.3.512"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.58.3.512","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,9]]},"assertion":[{"value":"1978-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}