{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:14:06Z","timestamp":1789391646594,"version":"build-2803163510"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1978,11]]},"abstract":"<jats:p>In 15 patients with severe chronic left ventricular failure, plasma renin activity (PRA) ranged widely, from 0.2--39 ng\/ml\/hr. The level of PRA was unrelated to cardiac output (CO) or pulmonary artery wedge pressure (PWP), but was slightly negatively correlated with mean arterial pressure (MAP) (r = -0.45) and systemic vascular resistance (SVR) (r = -0.40). After infusion of the angiotensin converting enzyme inhibitor teprotide (SQ 20,881) PWP fell from 26.3 +\/- 1.3 (SEM) to 20.3 +\/- 1.4 mm Hg (P less than 0.001), CO rose from 3.94 +\/- 0.23 to 4.75 +\/- 0.31 l\/min (P less than 0.001), MAP fell from 87.5 +\/- 3.8 to 77.9 +\/- 4.1 mm Hg (P less than 0.001) and SVR from 1619 +\/- 148 to 1252 +\/- 137 dyne-sec-cm-5 (P less than 0.001). The fall in MAP and in SVR was significantly correlated with control PRA (r = 0.68 and r = 0.58, respectively). When subjects were divided on the basis of control PRA the hemodynamic response to teprotide was greatest in the high renin group. PRA rose after teprotide (8.7 +\/- 3.4 to 37.9 +\/- 7.7 ng\/ml\/hr, P less than 0.05) but plasma norepinephrine fell (619.1 +\/- 103.6 to 449.7 +\/- 75.7, P less than 0.05). The renin-angiotensin system thus appears to have an important role in the elevated SVR in some patients with heart failure. Chronic inhibition of converting enzyme should be explored as a possible therapeutic approach.<\/jats:p>","DOI":"10.1161\/01.cir.58.5.763","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:57:40Z","timestamp":1339459060000},"page":"763-770","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":293,"title":["Role of the renin-angiotensin system in the systemic vasoconstriction of chronic congestive heart failure."],"prefix":"10.1161","volume":"58","author":[{"given":"C","family":"Curtiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J N","family":"Cohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Vrobel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Franciosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.58.5.763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:18:06Z","timestamp":1715527086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.58.5.763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1978,11]]}},"alternative-id":["10.1161\/01.CIR.58.5.763"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.58.5.763","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,11]]},"assertion":[{"value":"1978-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}