{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:31:35Z","timestamp":1787502695826,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1982,8]]},"abstract":"<jats:p>To evaluate the effects of prostacyclin (prostaglandin I2) on pulmonary vascular tone in primary pulmonary hypertension (PPH), we performed right-heart catheterization on seven patients with PPH and made hemodynamic measurements before and after infusing incremental doses of prostacyclin. In maximal doses of 2-12 mg\/kg\/min (mean 5.7 +\/0 3.1 ng\/kg\/min), prostacyclin reduced mean pulmonary arterial pressure from 62 +\/- 15 to 55 +\/- 16 mm Hg (p less than 0.05) and total pulmonary resistance from 17.1 +\/- 8.7 to 9.7 +\/- 5.9 units (p less than 0.005), and increased cardiac output from 4.22 +\/- 1.64 to 6.57 +\/- 2.04 l\/min (p less than 0.01). Heart rate increased from 83 +\/- 13 to 94 +\/- 11 beats\/min (p = 0.1) and mean systemic arterial pressure decreased from 90 +\/- 12 to 77 +\/- 4 mm Hg (p = 0.055). Three patients who received a continuous infusion of prostacyclin for 24-48 hours had sustained reductions in total pulmonary resistance during the infusion period. These data demonstrate that prostacyclin can increase cardiac output and reduce pulmonary arterial pressure and resistance in PPH.<\/jats:p>","DOI":"10.1161\/01.cir.66.2.334","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T16:29:13Z","timestamp":1308328153000},"page":"334-338","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":241,"title":["Prostacyclin-induced acute pulmonary vasodilation in primary pulmonary hypertension."],"prefix":"10.1161","volume":"66","author":[{"given":"L J","family":"Rubin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B M","family":"Groves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J T","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Frosolono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Handel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A E","family":"Cato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.66.2.334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T11:16:58Z","timestamp":1715512618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.66.2.334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,8]]}},"alternative-id":["10.1161\/01.CIR.66.2.334"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.66.2.334","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,8]]},"assertion":[{"value":"1982-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}