{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:11:00Z","timestamp":1792141860502,"version":"4.4.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:p>The long-term prognosis of variant angina and the factors influencing it were assessed in 217 consecutive patients hospitalized in our coronary care unit and followed for a mean of 65 months (range 2 to 123). Cardiac death occurred in 30 patients and an additional 54 experienced a nonfatal myocardial infarction. Survival at 1 and 5 years was 95% and 89%, respectively; survival without infarction was 83% and 69%. Coronary disease and the degree of disease activity were strong predictors of survival by Cox analysis. Survival at 1 year was 99%, and that at 5 years was 95% and 94%, respectively, for patients with one-vessel disease (n = 81) and for those without stenoses of 70% or greater (n = 87). Survival at 1 and 5 years was only 87% and 77% for those with multivessel disease (n = 40). The Cox analysis selected left ventricular function, initial treatment, extent score, duration of angina at rest, and disease activity as multivariate predictors of survival without infarction. Coronary disease was a strong predictor (p less than .0001) of survival without infarction by univariate analysis. Treatment with nifedipine, diltiazem, or verapamil improved survival without infarction compared with other medical treatment (p = .002). Myocardial infarction occurred most commonly soon after diagnosis in patients with a short history of angina at rest. Late coronary events were almost never preceded by resting angina.<\/jats:p>","DOI":"10.1161\/01.cir.76.5.990","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:29:13Z","timestamp":1308342553000},"page":"990-997","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":98,"title":["Long-term prognosis of patients with variant angina."],"prefix":"10.1161","volume":"76","author":[{"given":"A","family":"Walling","sequence":"first","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D D","family":"Waters","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D D","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G B","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Th\u00e9roux","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.76.5.990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:13:05Z","timestamp":1715526785000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.76.5.990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1987,11]]}},"alternative-id":["10.1161\/01.CIR.76.5.990"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.76.5.990","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11]]},"assertion":[{"value":"1987-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}