{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:36:26Z","timestamp":1770744986634,"version":"3.49.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:p>To compare the individual and combined electrophysiological effects of amiodarone and procainamide, 35 patients with sustained ventricular arrhythmias underwent programmed stimulation in the control state, after procainamide (mean concentration, 8.7 +\/- 2.8 micrograms\/ml), after 13 +\/- 2 days of amiodarone (1,400 mg\/day x 7 days, then 400 mg\/day), and after amiodarone with procainamide (mean procainamide concentration, 7.8 +\/- 2.2 micrograms\/ml). Sustained ventricular tachycardia (VT) was inducible in all 35 patients during treatment with procainamide alone and with amiodarone alone. Procainamide and amiodarone similarly increased the VT cycle length (+68 vs. +61 msec), the corrected QT interval (+63 vs. +49 msec), and the ventricular effective refractory period measured at paced cycle lengths of 600-550 msec (+23 vs. +21 msec) and 400 msec (+25 vs. +23 msec). Procainamide had a more pronounced effect on QRS duration than amiodarone during sinus rhythm (+18 vs. +8 msec, p less than 0.01) and during paced cycle lengths of 600-550 msec (+32 vs. +23 msec, p less than 0.01) and 400 msec (+37 vs. +28 msec, p less than 0.1) but a similar effect on the QRS duration during VT (+32 vs. +29 msec). During combination therapy, VT initiation was prevented in only two (6%) patients. The combination therapy produced a greater increase (p less than 0.001) than individual therapy in all the electrophysiological intervals assessed, with the exception of the sinus cycle length. On each drug regimen, a cycle length-dependent increase (p less than 0.05) in paced QRS duration was noted (400 more than 600-550 msec).(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.cir.78.3.583","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:29:13Z","timestamp":1308342553000},"page":"583-591","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Comparison of individual and combined effects of procainamide and amiodarone in patients with sustained ventricular tachyarrhythmias."],"prefix":"10.1161","volume":"78","author":[{"given":"F E","family":"Marchlinski","sequence":"first","affiliation":[{"name":"Clinical Electrophysiologic Laboratory, Hospital of the University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A E","family":"Buxton","sequence":"additional","affiliation":[{"name":"Clinical Electrophysiologic Laboratory, Hospital of the University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K E","family":"Kindwall","sequence":"additional","affiliation":[{"name":"Clinical Electrophysiologic Laboratory, Hospital of the University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Miller","sequence":"additional","affiliation":[{"name":"Clinical Electrophysiologic Laboratory, Hospital of the University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Clinical Electrophysiologic Laboratory, Hospital of the University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C D","family":"Gottlieb","sequence":"additional","affiliation":[{"name":"Clinical Electrophysiologic Laboratory, Hospital of the University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R B","family":"Bloom","sequence":"additional","affiliation":[{"name":"Clinical Electrophysiologic Laboratory, Hospital of the University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"Josephson","sequence":"additional","affiliation":[{"name":"Clinical Electrophysiologic Laboratory, Hospital of the University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.78.3.583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:00:07Z","timestamp":1715526007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.78.3.583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1161\/01.CIR.78.3.583"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.78.3.583","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]},"assertion":[{"value":"1988-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}