{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:38:17Z","timestamp":1783474697282,"version":"3.55.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1989,8]]},"abstract":"<jats:p>To determine correlates of survival in primary pulmonary hypertension, we compared 41 echocardiography-Doppler and nine catheterization parameters with outcome in 26 patients. Mean follow-up was 19.7 months in survivors; mean survival was 4.8 months in 16 nonsurvivors. Cox life-table univariate analysis correlated two echocardiographic, three Doppler, and three catheterization variables with poor survival (p less than or equal to 0.05), and chi 2 analysis ensured the best critical values: severity of pericardial effusion, heart rate of more than 87 beats\/min, pulmonic flow acceleration time of less than 62 msec, tricuspid early flow deceleration (T-DEC) equal to or less than -300 cm2\/sec, mitral early flow-to-atrial flow velocity ratio (M-E\/A) equal to or less than 1.0, catheterization cardiac index (CI) equal to or less than 2.3 l\/min\/m2, mean pulmonary artery pressure of more than 61 mm Hg, and diastolic pulmonary artery pressure of more than 43 mm Hg. Multivariate life-table analysis of noninvasive variables revealed the severity of pericardial effusion to be independently significant (p = 0.006), whereas analysis of catheterization variables revealed cardiac index to be independently significant (p = 0.014). Combined multivariate analysis did not differ from the noninvasive results alone. Categorical modeling of the eight significant variables split at their critical values (present or absent) revealed M-E\/A, T-DEC, and CI to be independently significant by multivariate analysis (p = 0.0014). Analysis of the five echocardiography-Doppler variables alone revealed M-E\/A, T-DEC, and heart rate to be independently significant (p = 0.0016). In both cases, mortality increased with the number of critical values reached.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.cir.80.2.353","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:29:13Z","timestamp":1308342553000},"page":"353-360","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":189,"title":["Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension."],"prefix":"10.1161","volume":"80","author":[{"given":"S B","family":"Eysmann","sequence":"first","affiliation":[{"name":"Hospital of the University of Pennsylvania, Cardiovascular Section, Philadelphia 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H I","family":"Palevsky","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania, Cardiovascular Section, Philadelphia 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Reichek","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania, Cardiovascular Section, Philadelphia 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Hackney","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania, Cardiovascular Section, Philadelphia 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P S","family":"Douglas","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania, Cardiovascular Section, Philadelphia 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.80.2.353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:04:47Z","timestamp":1715526287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.80.2.353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,8]]}},"alternative-id":["10.1161\/01.CIR.80.2.353"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.80.2.353","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,8]]},"assertion":[{"value":"1989-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}