{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:31:56Z","timestamp":1783675916452,"version":"3.55.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:p>To elucidate the pathogenic contribution of a potent vasoconstrictor, endothelin-1, to coronary artery spasm, we provoked spasm with intracoronary administration of acetylcholine or ergonovine and performed sensitive immunoassays of plasma levels of endothelin-1 and atrial natriuretic factor (ANF) in the peripheral vein and coronary sinus of patients with a tentative diagnosis of vasospastic angina (VSA, n = 19). The validity of coronary sinus blood sampling was verified by simultaneous measurement of the ANF level. The plasma endothelin-1 levels in venous and coronary sinus blood of the spasm-provoked patients (n = 12) were 1.71-fold and 2.16-fold higher, respectively, than those of nonprovoked cases (n = 5, p less than 0.01). During left coronary spasm, the endothelin-1 level in coronary sinus transiently decreased from 2.27 +\/- 0.14 to 1.76 +\/- 0.14 pg\/ml (p less than 0.01) and returned to the control level (1.98 +\/- 0.20 pg\/ml) after the spasm resolved, whereas the change was equivocal during right coronary spasm. In contrast, the patients in whom spasm was not provoked showed no changes and maintained low endothelin-1 levels both before and after the maximal provocation (0.90 +\/- 0.13 versus 0.90 +\/- 0.13 pg\/ml).(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.cir.83.2.476","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:01:09Z","timestamp":1339459269000},"page":"476-483","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":179,"title":["Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris."],"prefix":"10.1161","volume":"83","author":[{"given":"T","family":"Toyo-oka","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine, University of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Hirata","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W S","family":"Shin","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Masaki","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.83.2.476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:40:53Z","timestamp":1715528453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.83.2.476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,2]]}},"alternative-id":["10.1161\/01.CIR.83.2.476"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.83.2.476","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,2]]},"assertion":[{"value":"1991-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}