{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:18:29Z","timestamp":1756991909662},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:p>The effect of long-term oral administration of antiarrhythmic drugs on defibrillation energy requirements is not well understood. We examined the effect of clofilium, a drug that prolongs cardiac action potential duration without slowing cardiac conduction, on defibrillation energy requirements and ventricular effective refractory periods in a canine model during a 3-week period. Epicardial patch electrodes were implanted in 12 dogs, and baseline testing was conducted under fentanyl anesthesia on day 7. An oral clofilium (100 mg\/day) regimen was started on day 8. Six clofilium-treated and six control dogs underwent repeated testing on days 14, 21, and 28 after surgery. Truncated trapezoidal shocks were given repeatedly at various stored energies in random order; delivered current and impedance were measured; and delivered energy was calculated. The energy and current for 50% success in defibrillation (E50 and I50, respectively) were determined. For control animals, E50 increased by a mean 34 +\/- 78%, 60 +\/- 83%, and 69 +\/- 122% compared with baseline (day 7) on days 14, 21, and 28, respectively. In contrast, E50 in clofilium-treated dogs decreased by 39 +\/- 62%, 24 +\/- 33%, and 32 +\/- 15% on days 14, 21, and 28, respectively. Mean current requirements (I50) remained relatively stable compared with baseline in control animals (-7 +\/- 39%, +25 +\/- 36%, +40 +\/- 75% on days 14, 21, and 28, respectively). After clofilium administration I50 decreased by 36 +\/- 22%, 32 +\/- 17%, and 33 +\/- 17% on days 14, 21, and 28, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.cir.83.2.614","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:01:09Z","timestamp":1339459269000},"page":"614-621","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Oral clofilium produces sustained lowering of defibrillation energy requirements in a canine model."],"prefix":"10.1161","volume":"83","author":[{"given":"P","family":"Dorian","sequence":"first","affiliation":[{"name":"Department of Medicine, Toronto Western Hospital, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Toronto Western Hospital, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"David","sequence":"additional","affiliation":[{"name":"Department of Medicine, Toronto Western Hospital, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Feindel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Toronto Western Hospital, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.83.2.614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:40:43Z","timestamp":1715528443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.83.2.614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,2]]}},"alternative-id":["10.1161\/01.CIR.83.2.614"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.83.2.614","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,2]]},"assertion":[{"value":"1991-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}