{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:48:16Z","timestamp":1777423696300,"version":"3.51.4"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>The \"Western\" diet, sex, and apolipoprotein (Apo) E polymorphism have been implicated as codeterminants of lipid levels.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS AND RESULTS<\/jats:title>\n            <jats:p>In a retrospective analysis, we evaluated the combined impact of dietary fat, sex, and Apo E phenotype on lipoprotein levels in 67 subjects fed two contrasting, metabolically controlled diets: one a \"Western\" diet, with a low polyunsaturated to saturated (P:S) fatty acid ratio and the other a \"therapeutic\" diet, with a high P:S ratio. The high P:S diet compared with P:S diet exerted a far stronger predictive influence on lipoprotein concentrations than Apo E phenotype, sex, or the latter two factors combined. Apo E phenotype alone was associated with a stepwise increase in low density lipoprotein cholesterol (LDL-C), such that 3\/2 less than 3\/3 less than 4\/3 on either the low or the high P:S diets. On the low P:S diet only, sex was shown to be a significant predictor of high density lipoprotein cholesterol (HDL-C) levels, with women greater than men, and the associated LDL\/HDL ratio with men greater than women. On the high P:S diet, women displayed a dramatic fall in HDL-C, effectively raising the LDL\/HDL ratio to equivalency with men and obliterating the sex influence seen with the low P:S diet. Controlled for dietary fat, Apo E and sex exerted independent, additive effects on lipoprotein levels on the low P:S diet only. Only the Apo E phenotype remained predictive on the high P:S diet.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS<\/jats:title>\n            <jats:p>Women of the Apo E 3\/2 phenotype stand to benefit the least from a high P:S diet because of reduction in the more \"protective\" HDL-C, whereas men of the 4\/3 phenotype showed the greatest improvement in the LDL\/HDL ratio.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/01.cir.86.3.849","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:01:09Z","timestamp":1339459269000},"page":"849-857","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Influence of dietary fat, apolipoprotein E phenotype, and sex on plasma lipoprotein levels."],"prefix":"10.1161","volume":"86","author":[{"given":"M M","family":"Cobb","sequence":"first","affiliation":[{"name":"Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Teitlebaum","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Risch","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Jekel","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ostfeld","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.86.3.849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:33:09Z","timestamp":1715527989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.86.3.849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1161\/01.CIR.86.3.849"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.86.3.849","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]},"assertion":[{"value":"1992-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}