{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:08:50Z","timestamp":1793506130950,"version":"4.5.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>We examined the clinical and echocardiographic characteristics of patients undergoing aortic valve replacement for aortic stenosis whose continuous wave Doppler studies showed abnormal intracavitary flow acceleration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS AND RESULTS<\/jats:title>\n            <jats:p>The clinical and Doppler echocardiographic records of 53 consecutive patients undergoing aortic valve replacement for aortic stenosis were reviewed. Doppler echocardiography was performed at a mean of 6.6 days (range, 0-22 days) after surgery. Thirteen patients (group 1) had a dagger-shaped high-velocity systolic flow signal indicative of abnormal intracavitary flow acceleration on their postoperative Doppler study; group 2 comprised 40 aortic stenosis patients who underwent aortic valve replacement but had no postoperative evidence of abnormal intracavitary flow acceleration. Group 1 postoperative abnormal intracavitary flow velocities ranged from 1.8 to 6.8 m\/sec (mean, 4.9 +\/- 0.9 m\/sec): Resulting dynamic gradients ranged from 10 to 184 mm Hg (mean, 104.6 +\/- 32 mm Hg). Compared with group 2, group 1 patients had a distinctive ventricular geometry with more-pronounced hypertrophy, smaller cavities, and higher ejection fraction. Systolic anterior motion of the mitral valve did not accompany abnormal intracavitary flow acceleration in any patient. Six of 13 group 1 patients suffered postoperative hemodynamic compromise characterized by severe hypotension despite adequate pulmonary capillary wedge pressures; group 1 postoperative mortality was significantly greater than that seen in group 2 patients (38% versus 12%, p less than 0.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS<\/jats:title>\n            <jats:p>Abnormal intracavitary flow acceleration after aortic valve replacement for severe aortic stenosis is associated with a distinctive ventricular geometry and supernormal systolic function but not systolic anterior motion of the mitral valve. Such flow acceleration appears to be a marker for increased postoperative morbidity and mortality. Preoperative and postoperative Doppler echocardiography may be useful in risk stratification and guiding therapy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/01.cir.86.3.926","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:01:09Z","timestamp":1339459269000},"page":"926-936","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":126,"title":["Abnormal left ventricular intracavitary flow acceleration in patients undergoing aortic valve replacement for aortic stenosis. A marker for high postoperative morbidity and mortality."],"prefix":"10.1161","volume":"86","author":[{"given":"G","family":"Aurigemma","sequence":"first","affiliation":[{"name":"Noninvasive Laboratory, University of Massachusetts Medical Center, Worcester 01655."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Battista","sequence":"additional","affiliation":[{"name":"Noninvasive Laboratory, University of Massachusetts Medical Center, Worcester 01655."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Orsinelli","sequence":"additional","affiliation":[{"name":"Noninvasive Laboratory, University of Massachusetts Medical Center, Worcester 01655."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Noninvasive Laboratory, University of Massachusetts Medical Center, Worcester 01655."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Pape","sequence":"additional","affiliation":[{"name":"Noninvasive Laboratory, University of Massachusetts Medical Center, Worcester 01655."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Cu\u00e9noud","sequence":"additional","affiliation":[{"name":"Noninvasive Laboratory, University of Massachusetts Medical Center, Worcester 01655."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.86.3.926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:33:23Z","timestamp":1715528003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.86.3.926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1161\/01.CIR.86.3.926"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.86.3.926","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]},"assertion":[{"value":"1992-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}