{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:14:23Z","timestamp":1791267263188,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>Diabetic subjects have a high incidence of cardiovascular accidents, with an altered circadian distribution. Abnormalities in the circadian rhythm of autonomic tone may be responsible for this altered temporal onset of cardiovascular disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS AND RESULTS<\/jats:title>\n            <jats:p>To assess circadian changes of sympathovagal balance in diabetes, we performed 24-hour power spectral analysis of RR interval fluctuations in 54 diabetic subjects (age, 44 +\/- 2 years) with either normal autonomic function or mild to severe autonomic neuropathy and in 54 age-matched control subjects. The power in the low-frequency (LF, 0.03-0.15 Hz) and high-frequency (HF, 0.18-0.40 Hz) bands was considered an index of relative sympathetic and vagal activity, respectively. Diabetic subjects with autonomic abnormalities showed a reduction in LF compared with control subjects (5.95 +\/- 0.12 In-msec2 versus 6.73 +\/- 0.11, p &lt; 0.001) and an even greater reduction in LF, particularly during the night and the first hours after awakening (5.11 +\/- 0.18 In-msec2 versus 6.52 +\/- 0.14, p &lt; 0.001). Day-night rhythm in sympathovagal balance was reduced or absent in diabetic subjects compared with control subjects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS<\/jats:title>\n            <jats:p>Diabetic subjects with or without signs of autonomic neuropathy have a decreased vagal activity (and hence a relatively higher sympathetic activity) during night hours and at the same time of the day, during which a higher frequency of cardiovascular accidents has been reported. These observations may provide insight into the increased cardiac risk of diabetic patients, particularly if autonomic neuropathy is present.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/01.cir.86.5.1443","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:01:09Z","timestamp":1339459269000},"page":"1443-1452","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":168,"title":["Impaired circadian modulation of sympathovagal activity in diabetes. A possible explanation for altered temporal onset of cardiovascular disease."],"prefix":"10.1161","volume":"86","author":[{"given":"L","family":"Bernardi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, First Medical Clinics, University of Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Ricordi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, First Medical Clinics, University of Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Lazzari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, First Medical Clinics, University of Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Sold\u00e1","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, First Medical Clinics, University of Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Calciati","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, First Medical Clinics, University of Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M R","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, First Medical Clinics, University of Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Vandea","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, First Medical Clinics, University of Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Finardi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, First Medical Clinics, University of Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Fratino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, First Medical Clinics, University of Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.86.5.1443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:08:27Z","timestamp":1715530107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.86.5.1443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,11]]}},"alternative-id":["10.1161\/01.CIR.86.5.1443"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.86.5.1443","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11]]},"assertion":[{"value":"1992-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}