{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:24:05Z","timestamp":1776399845639,"version":"3.51.2"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>Despite two decades of research, a transcatheter atrial septal defect closure device is not available for clinical use. We have designed a new superelastic Nitinol-Dacron, double-disk, self-centering, atrial septal defect closure device and studied its efficacy in a canine model of atrial septal defects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS AND RESULTS<\/jats:title>\n            <jats:p>Atrial septal defects were created surgically in 20 adult dogs using either a 7.5-mm or 10-mm punch. Percutaneous transcatheter closures were attempted using a new device. The device sizes used were 20 mm in 6 dogs, 22 mm in 9, and 25 mm in 5 (22.1 +\/- 1.9 mm, mean +\/- SD). The stretched atrial septal defect diameter was 10.5 +\/- 1.3 mm, and the device to stretched atrial septal defect diameter ratio was 2.1 +\/- 0.3. Closures were successful in 19 studies and unsuccessful in 1. Angiography showed a left-to-right shunt in all 20 dogs before closure. Immediately after closure (n = 19), there were no shunts in 17 and trivial shunts in 2. Six dogs were followed for a period of 4.7 +\/- 3.0 months (range, 2 to 8 months). The trivial shunt present in 1 animal immediately after closure had closed by the time of the repeat study. Spontaneous embolization of the device was not seen during follow-up. A solitary wire fracture was found 8 months after closure in 1 device. Light microscopy at 8 weeks in 3 dogs showed the devices to be covered by smooth endocardium, enmeshed in mature collagen tissue, with a minimal mononuclear cell infiltration. Retrievability was assessed by deliberately embolizing 4 devices in 2 dogs into the right atrium (n = 1) and pulmonary artery (n = 3). All devices were successfully retrieved with a snare.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS<\/jats:title>\n            <jats:p>This feasibility study demonstrates that this new self-centering atrial septal defect closure device has a number of design features that permit effective and safe closures in a canine model. These results support the investigation of this device in human clinical trials.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/01.cir.88.4.1754","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:01:09Z","timestamp":1339459269000},"page":"1754-1764","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":147,"title":["Experimental atrial septal defect closure with a new, transcatheter, self-centering device."],"prefix":"10.1161","volume":"88","author":[{"given":"G S","family":"Das","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Minnesota Medical School, Minneapolis 55455."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota Medical School, Minneapolis 55455."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota Medical School, Minneapolis 55455."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Wyche","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota Medical School, Minneapolis 55455."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Gunther","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota Medical School, Minneapolis 55455."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R F","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota Medical School, Minneapolis 55455."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.88.4.1754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:54:07Z","timestamp":1715529247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.88.4.1754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,10]]}},"alternative-id":["10.1161\/01.CIR.88.4.1754"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.88.4.1754","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10]]},"assertion":[{"value":"1993-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}