{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:45:05Z","timestamp":1791092705631,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Antiplatelet therapy with aspirin and antithrombotic therapy with heparin both prevent the complications of unstable angina; however, no definitive data exist on the relative clinical efficacy of the two drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS AND RESULTS<\/jats:title>\n                    <jats:p>Aspirin (325 mg bid) or heparin (5000-U intravenous bolus followed by a perfusion titrated to the APTT) were compared in a double-blind randomized trial of 484 patients in two cohorts enrolled sequentially. The study was initiated at admission to hospital at a mean of 8.3 +\/- 7.8 hours after the last episode of pain. End points were assessed 5.7 +\/- 3.3 days later, when the decision for long-term management was made. Myocardial infarction occurred in 2 (0.8%) of the 240 patients randomized to heparin and in 9 (3.7%) of the 244 randomized to aspirin (P = .035), an odds ratio of 0.22 and a risk difference of 2.9% (95% confidence limits, 0.3% to 5.6%) with heparin. The only death resulted from a myocardial infarction in an aspirin patient. Survival curves with Cox logistic regression analysis showed that the improvement in survival without myocardial infarction with heparin (P = .035) was independent of other baseline characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This study documents that heparin prevents myocardial infarction better than aspirin during the acute phase of unstable angina.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/01.cir.88.5.2045","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T20:01:09Z","timestamp":1339444869000},"page":"2045-2048","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":205,"title":["Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina."],"prefix":"10.1161","volume":"88","author":[{"given":"P","family":"Th\u00e9roux","sequence":"first","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Waters","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"McCans","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"de Guise","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Juneau","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.88.5.2045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T11:54:15Z","timestamp":1715514855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.88.5.2045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["10.1161\/01.CIR.88.5.2045"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.88.5.2045","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11]]},"assertion":[{"value":"1993-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}