{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:29:27Z","timestamp":1787509767978,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The long-term clinical issue in Kawasaki disease (KD) concerns the coronary artery lesion. Two-dimensional echocardiography and coronary angiography are routine examinations to evaluate the coronary lesions; however, these are not adequate to assess the wall morphology of the coronary artery (CA). Intravascular ultrasound imaging (IVUS), a new technology for the evaluation of the coronary artery lumen and wall morphology in vivo, was performed for patients after KD in their long-term follow-up, and we examined the new insights it gave.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS AND RESULTS<\/jats:title>\n                    <jats:p>IVUS was performed during cardiac catheterization in 20 subjects (10 patients after KD who still had coronary aneurysms or regressed coronary aneurysms, 2 after KD who had no coronary abnormal lesion, and 8 control patients with congenital heart disease and normal CA). We evaluated the wall structure at 10 to 15 sites of the CA in each patient. IVUS was performed with a commercially available ultrasound imaging catheter. Four sites of a CA aneurysm in KD demonstrated a markedly dilated lumen without thickened intima. One site of a CA aneurysm with calcification demonstrated an asymmetrical lumen by a dense echo with acoustic shadows. Twenty-two sites of a regressed CA aneurysm demonstrated a marked symmetrical or asymmetrical thickening of the intima with a dense echo, in which the size of the lumen was similar to that at a site near a regressed aneurysm. The sites of angiographically normal CA revealed normal structures and a thin intima in many instances. Nine of 28 sites in KD with a CA abnormal lesion, particularly near a coronary aneurysm or regressed aneurysm, demonstrated a mild thickening of the intima. All the 10 sites in KD without a CA abnormal lesion and all the 25 sites in patients with congenital heart disease with normal CA demonstrated a smooth intima.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This study demonstrated that the site of a regressed coronary aneurysm has a markedly thickened but smooth intima. The sites of angiographically normal CA after KD with or without a coronary lesion demonstrated normal IVUS findings in most instances but in some cases revealed a mild intimal thickening. IVUS is useful to evaluate the CA wall morphology and may contribute to the assessment of long-term CA sequelae and the possible development of arteriosclerotic changes in KD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/01.cir.89.1.258","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T20:34:42Z","timestamp":1339446882000},"page":"258-265","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":144,"title":["Intravascular ultrasound of coronary arteries in children. Assessment of the wall morphology and the lumen after Kawasaki disease."],"prefix":"10.1161","volume":"89","author":[{"given":"T","family":"Sugimura","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Kurume University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kurume University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kurume University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kurume University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kurume University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kurume University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kurume University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Akagi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kurume University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Maeno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kurume University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kurume University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.89.1.258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T12:03:42Z","timestamp":1715515422000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.89.1.258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1161\/01.CIR.89.1.258"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.89.1.258","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]},"assertion":[{"value":"1994-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}