{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:11:01Z","timestamp":1782270661657,"version":"3.54.5"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            It has been reported that the\n            <jats:italic>D<\/jats:italic>\n            allele of an insertion\/deletion (\n            <jats:italic>I\/D<\/jats:italic>\n            ) polymorphism of the angiotensin I\u2013converting enzyme (ACE) gene is associated with conditions of increased cardiovascular risk, including left ventricular hypertrophy.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Considering that a genetically determined overactivity of the renin-angiotensin system may influence cardiac as well as vascular growth, we investigated possible relations between ACE\n            <jats:italic>I\/D<\/jats:italic>\n            genotype and carotid artery wall thickness (B-mode ultrasound) in 199 subjects, 50 to 64 years old, sampled from the general population of Vobarno, a small town in northern Italy. ACE\n            <jats:italic>DD<\/jats:italic>\n            genotype was associated with significantly higher common carotid artery intima-media thickness (\n            <jats:italic>P<\/jats:italic>\n            =.003). The occurrence of carotid atherosclerotic plaques was similar in the different genotypes. There was no association of the ACE\n            <jats:italic>I\/D<\/jats:italic>\n            genotype with blood pressure values (either casual or 24-hour ambulatory monitored).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            ACE\n            <jats:italic>DD<\/jats:italic>\n            genotype may be considered a risk factor for the development of common carotid intima-media thickening in our study population.\n          <\/jats:p>","DOI":"10.1161\/01.cir.91.11.2721","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"2721-2724","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["Angiotensin-Converting Enzyme\n            <i>I\/D<\/i>\n            Polymorphism and Arterial Wall Thickness in a General Population"],"prefix":"10.1161","volume":"91","author":[{"given":"Maurizio","family":"Castellano","sequence":"first","affiliation":[{"name":"From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women\u2019s Hospital, Boston, Mass (R.K., K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lorenza","family":"Muiesan","sequence":"additional","affiliation":[{"name":"From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women\u2019s Hospital, Boston, Mass (R.K., K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiano","family":"Rizzoni","sequence":"additional","affiliation":[{"name":"From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women\u2019s Hospital, Boston, Mass (R.K., K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Beschi","sequence":"additional","affiliation":[{"name":"From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women\u2019s Hospital, Boston, Mass (R.K., K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Pasini","sequence":"additional","affiliation":[{"name":"From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women\u2019s Hospital, Boston, Mass (R.K., K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Cinelli","sequence":"additional","affiliation":[{"name":"From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women\u2019s Hospital, Boston, Mass (R.K., K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Salvetti","sequence":"additional","affiliation":[{"name":"From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women\u2019s Hospital, Boston, Mass (R.K., K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Porteri","sequence":"additional","affiliation":[{"name":"From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women\u2019s Hospital, Boston, Mass (R.K., K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Bettoni","sequence":"additional","affiliation":[{"name":"From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women\u2019s Hospital, Boston, Mass (R.K., K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"Kreutz","sequence":"additional","affiliation":[{"name":"From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women\u2019s Hospital, Boston, Mass (R.K., K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Lindpaintner","sequence":"additional","affiliation":[{"name":"From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women\u2019s Hospital, Boston, Mass (R.K., K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico Agabiti","family":"Rosei","sequence":"additional","affiliation":[{"name":"From Semeiotica Medica, Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia and I Divisione Medicina Generale, Spedali Civili di Brescia (M.C., M.L.M., D.R., M.B., A.C., M.S., E.P., G.B., E.A.R.); the Divisione Medicina Generale, Ospedale di Gavardo (G.P.); and Brigham and Women\u2019s Hospital, Boston, Mass (R.K., K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114844"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/359641a0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91075-W"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92268-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1993.tb03904.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1293-324"},{"key":"e_1_3_2_7_2","unstructured":"Ludwig EH Corneli PS Anderson JL Marshall HW Lalouel JM Ward RH. 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