{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:37:44Z","timestamp":1774665464134,"version":"3.50.1"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1995,2,15]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            The effects of early pressure overload on left ventricular (LV) chamber mechanics in the primate heart are poorly understood.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            To test the hypothesis that early LV pressure overload hypertrophy is associated with depression of velocity-dependent indices of LV systolic (LV dP\/dt) and diastolic function (time constant of relaxation, tau) but unchanged systolic elastance (E\n            <jats:sub>es<\/jats:sub>\n            ), we studied six conscious baboons instrumented with LV micromanometers and LV dimension and wall thickness sonomicrometers. Loading conditions were altered by pharmacological angiotensin II generation both before and 12 weeks after producing renovascular hypertension (2 kidney, 1 clip). The LV systolic pressure (149\u00b111 [SD] versus 114\u00b15 mm Hg) and LV mass (125\u00b125 versus 91\u00b120 g) were greater 12 weeks after than before (both\n            <jats:italic>P<\/jats:italic>\n            &lt;.05). Both E\n            <jats:sub>es<\/jats:sub>\n            and E\n            <jats:sub>es<\/jats:sub>\n            normalized for LV mass were similar before versus 12 weeks after (23.0\u00b19.6 versus 22.3\u00b19.8 mm Hg\/mL and 26.5\u00b114.5 versus 19.8\u00b112.5 mm Hg\/mL, respectively; both\n            <jats:italic>P<\/jats:italic>\n            =NS). At matched LV systolic and diastolic pressures, LV fractional shortening was similar (18.6\u00b16.8% versus 21.6\u00b14.9%), but the time constant of LV isovolumic relaxation was significantly longer (42.3\u00b15.3 versus 31.4\u00b17.0 ms,\n            <jats:italic>P<\/jats:italic>\n            &lt;.05) and LV dP\/dt and V\n            <jats:sub>cf<\/jats:sub>\n            were significantly less (1891\u00b1352 versus 2342\u00b1284 mm Hg\/s and 0.9\u00b10.4 versus 1.1\u00b10.3 circ\/s, respectively; both\n            <jats:italic>P<\/jats:italic>\n            &lt;.05) 12 weeks after than before.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            In conscious baboons with systemic arterial hypertension and early LV hypertrophy, there is depression of velocity-dependent indices of LV contraction and relaxation but unaltered force-dependent measures of contractility.\n          <\/jats:p>","DOI":"10.1161\/01.cir.91.4.1213","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"1213-1220","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Disparate Effects of Early Pressure Overload Hypertrophy on Velocity-Dependent and Force-Dependent Indices of Ventricular Performance in the Conscious Baboon"],"prefix":"10.1161","volume":"91","author":[{"given":"Brian D.","family":"Hoit","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, University of Cincinnati Medical Center, Cincinnati, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfu","family":"Shao","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, University of Cincinnati Medical Center, Cincinnati, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie","family":"Gabel","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, University of Cincinnati Medical Center, Cincinnati, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Walsh","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, University of Cincinnati Medical Center, Cincinnati, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"H418","volume":"232","year":"1977","unstructured":"Sasayama S, Franklin D, Ross J Jr. Hyperfunction with normal inotropic state of the hypertrophied left ventricle. 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Circ Res. 1973;28:234-245.","journal-title":"Circ Res"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.10.3.339"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.44.3.446"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.50.4.6461437"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.66.4.2317899"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114042"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/27.3.416"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108522"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.76.6.3677352"},{"key":"e_1_3_2_19_2","unstructured":"Effects of growth and aging of organism on ESPVR: normalization of Ees for heart size. In: Sagawa K Mauchan L Suga H Sunagawa K eds. Cardiac Contraction and the Pressure-Volume Relationship. 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Calcium and cardiac relaxation. In: Grossman W Lorell BH eds. Diastolic Relaxation of the Heart. 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