{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:17:28Z","timestamp":1792721848785,"version":"4.5.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1995,12,15]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Studies of patients with coronary artery disease and left ventricular dysfunction have shown that preoperative quantification of myocardial viability may be clinically useful to identify those patients who will benefit most from revascularization both functionally and prognostically. However, the relation between preoperative extent of viability and change in heart failure symptoms has not been documented carefully. We assessed the relation between the magnitude of improvement in heart failure symptoms after coronary artery bypass surgery (CABG) and the extent of myocardial viability as assessed by use of quantitative analysis of preoperative positron emission tomography (PET) images.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            We studied 36 patients with ischemic cardiomyopathy (mean left ventricular ejection fraction, 28\u00b16%) undergoing CABG. Preoperative extent and severity of perfusion abnormalities and myocardial viability (flow-metabolism mismatch) were assessed by use of quantitative analysis of PET images with\n            <jats:sup>13<\/jats:sup>\n            N ammonia and fluorine-18-deoxyglucose. Each patient\u2019s functional status was determined before and after CABG by use of a Specific Activity Scale. Mean perfusion defect size and severity were 63\u00b113% and 33\u00b112%, respectively. Total extent of a PET mismatch correlated linearly and significantly with percent improvement in functional status after CABG (\n            <jats:italic>r<\/jats:italic>\n            =.87,\n            <jats:italic>P<\/jats:italic>\n            &lt;.0001). A blood flow\u2013metabolism mismatch \u226518% was associated with a sensitivity of 76% and a specificity of 78% for predicting a change in functional status after revascularization. Patients with large mismatches (\u226518%) achieved a significantly higher functional status compared with those with minimal or no PET mismatch (&lt;5%) (5.7\u00b10.8 versus 4.9\u00b10.7 metabolic equivalents,\n            <jats:italic>P<\/jats:italic>\n            =.009). This resulted in an improvement of 107% in patients with large mismatches compared with only 34% in patients with minimal or no PET mismatch.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            In patients with ischemic cardiomyopathy, the magnitude of improvement in heart failure symptoms after CABG is related to the preoperative extent and magnitude of myocardial viability as assessed by use of PET imaging. Patients with large perfusion-metabolism mismatches exhibit the greatest clinical benefit after CABG.\n          <\/jats:p>","DOI":"10.1161\/01.cir.92.12.3436","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"3436-3444","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":361,"title":["Quantitative Relation Between Myocardial Viability and Improvement in Heart Failure Symptoms After Revascularization in Patients With Ischemic Cardiomyopathy"],"prefix":"10.1161","volume":"92","author":[{"given":"Marcelo F.","family":"Di Carli","sequence":"first","affiliation":[{"name":"From the Division of Nuclear Medicine, Department of Medical and Molecular Pharmacology, Laboratory of Nuclear Medicine, Laboratory of Biomedical and Environmental Sciences; the Crump Institute for Biological Imaging; and the Division of Cardiothoracic Surgery (H.L.), Department of Surgery, University of California at Los Angeles, School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farbod","family":"Asgarzadie","sequence":"additional","affiliation":[{"name":"From the Division of Nuclear Medicine, Department of Medical and Molecular Pharmacology, Laboratory of Nuclear Medicine, Laboratory of Biomedical and Environmental Sciences; the Crump Institute for Biological Imaging; and the Division of Cardiothoracic Surgery (H.L.), Department of Surgery, University of California at Los Angeles, School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich R.","family":"Schelbert","sequence":"additional","affiliation":[{"name":"From the Division of Nuclear Medicine, Department of Medical and Molecular Pharmacology, Laboratory of Nuclear Medicine, Laboratory of Biomedical and Environmental Sciences; the Crump Institute for Biological Imaging; and the Division of Cardiothoracic Surgery (H.L.), Department of Surgery, University of California at Los Angeles, School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Brunken","sequence":"additional","affiliation":[{"name":"From the Division of Nuclear Medicine, Department of Medical and Molecular Pharmacology, Laboratory of Nuclear Medicine, Laboratory of Biomedical and Environmental Sciences; the Crump Institute for Biological Imaging; and the Division of Cardiothoracic Surgery (H.L.), Department of Surgery, University of California at Los Angeles, School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillel","family":"Laks","sequence":"additional","affiliation":[{"name":"From the Division of Nuclear Medicine, Department of Medical and Molecular Pharmacology, Laboratory of Nuclear Medicine, Laboratory of Biomedical and Environmental Sciences; the Crump Institute for Biological Imaging; and the Division of Cardiothoracic Surgery (H.L.), Department of Surgery, University of California at Los Angeles, School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Phelps","sequence":"additional","affiliation":[{"name":"From the Division of Nuclear Medicine, Department of Medical and Molecular Pharmacology, Laboratory of Nuclear Medicine, Laboratory of Biomedical and Environmental Sciences; the Crump Institute for Biological Imaging; and the Division of Cardiothoracic Surgery (H.L.), Department of Surgery, University of California at Los Angeles, School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamshid","family":"Maddahi","sequence":"additional","affiliation":[{"name":"From the Division of Nuclear Medicine, Department of Medical and Molecular Pharmacology, Laboratory of Nuclear Medicine, Laboratory of Biomedical and Environmental Sciences; the Crump Institute for Biological Imaging; and the Division of Cardiothoracic Surgery (H.L.), Department of Surgery, University of California at Los Angeles, School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198909000-00011"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)39418-8"},{"key":"e_1_3_2_3_2","first-page":"766","volume":"64","year":"1981","unstructured":"Marshall RC, Tillisch JH, Phelps ME, Huang SC, Carson RC, Henze E, Schelbert HR. Identification and differentiation of resting myocardial ischemia and infarction in man with positron computed tomography 18F-labeled fluorodeoxyglucose and N-13 ammonia. Circulation. 1981;64:766-778.","journal-title":"Circulation"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.73.5.3486054"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198604033141405"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90832-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00168164"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/1010-7940(92)90244-R"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90582-L"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.85.4.1555279"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(83)90304-1"},{"key":"e_1_3_2_12_2","first-page":"1718","volume":"23","year":"1991","unstructured":"Mori T, Minamiji K, Kurongane H, Ogawa K, Yoshida Y. Rest-injected thallium-201 imaging for assessing viability of severe asynergic regions. J Nucl Med.. 1991;23:1718-1724.","journal-title":"J Nucl Med."},{"key":"e_1_3_2_13_2","first-page":"1630","volume":"86","year":"1993","unstructured":"Ragosta M, Beller GA, Watson DD, Kaul S, Gimple W. Quantitative planar rest-redistribution Tl-201 imaging in detection of myocardial viability and prediction of improvement in left ventricular function after coronary artery bypass surgery in patients with severely depressed left ventricular function. Circulation. 1993;86:1630-1641.","journal-title":"Circulation"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007193230301"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90692-T"},{"key":"e_1_3_2_16_2","first-page":"673","volume":"32","year":"1991","unstructured":"Tamaki N, Ohtani H, Yamashita K, Magata Y, Yonekura Y, Nohara R, Kambara H, Kawai C, Hirata K, Ban T, Konishi J. Metabolic activity in the areas of new fill-in after thallium-201 reinjection: comparison with positron emission tomography. J Nucl Med.. 1991;32:673-678.","journal-title":"J Nucl Med."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90755-X"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90327-1"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.64.6.7296795"},{"key":"e_1_3_2_20_2","first-page":"25","volume":"41","year":"1972","unstructured":"Fox SM, Naughton JP, Gorman PA. Physical activity and cardiovascular health, III: the exercise prescription, frequency and type of activity. Mod Concepts Cardiovasc Dis.. 1972;41:25-30.","journal-title":"Mod Concepts Cardiovasc Dis."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(76)80106-8"},{"key":"e_1_3_2_22_2","first-page":"1628","volume":"33","year":"1992","unstructured":"Porenta G, Kuhle W, Czernin J, Ratib O, Brunken RC, Phelps ME, Schelbert HR. Semiquantitative assessment of myocardial blood flow and viability using polar map displays of cardiac PET images. J Nucl Med.. 1992;33:1628-1636.","journal-title":"J Nucl Med."},{"key":"e_1_3_2_23_2","first-page":"2031","volume":"35","year":"1994","unstructured":"Sun KT, De Groof M, Yi J, Hansen HW, Chen K, Czernin J, Phelps M, Schelbert HR. Quantification of the extent and severity of perfusion defects in canine myocardium by PET polar mapping. J Nucl Med.. 1994;35:2031-2040.","journal-title":"J Nucl Med."},{"key":"e_1_3_2_24_2","unstructured":"Wilkinson Leland. SYSTAT: The System for Statistics. Evanston Ill: SYSTAT Inc; 1989:180-280."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-2998(78)80014-2"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90008-B"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90407-R"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.6.7994809"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.68.4.6352078"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.86.6.1451239"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.74.4.3757193"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/13.9.514"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.66.6.6216024"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(85)90640-4"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.72.1.4006123"},{"key":"e_1_3_2_36_2","unstructured":"Khanna S Di Carli M Dahlbom M Rokhsar S Sumida R Hawkins R Phelps ME Maddahi J. Improved assessment of myocardial viability by PET metabolic imaging in patients undergoing rest-stress myocardial perfusion study. Circulation. 1992;86(suppl I):I-109. Abstract."},{"key":"e_1_3_2_37_2","first-page":"49P","volume":"35","year":"1994","unstructured":"Hansen CL, Heo J, Oliner C, Van Decker W, Iskandrian AS. Prediction of functional recovery with I-123 phenylpentadecanoic acid after coronary revascularization. J Nucl Med.. 1994;35:49P. Abstract.","journal-title":"J Nucl Med."},{"key":"e_1_3_2_38_2","first-page":"176","volume":"36","year":"1995","unstructured":"Burt RW, Perkins OW, Oppenheim BE, Schauwecker DS, Stein L, Wellman HN, Witt RM. Direct comparison of fluorine-18-FDG SPECT, fluorine-18-FDG PET and rest thallium-201 SPECT for detection of myocardial viability. J Nucl Med.. 1995;36:176-179.","journal-title":"J Nucl Med."}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.92.12.3436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:54:15Z","timestamp":1715529255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.92.12.3436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12,15]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1995,12,15]]}},"alternative-id":["10.1161\/01.CIR.92.12.3436"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.92.12.3436","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12,15]]},"assertion":[{"value":"1995-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-08-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-12-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}