{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:33:21Z","timestamp":1770824001612,"version":"3.50.1"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1995,7,15]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Cardiac allograft vasculopathy (CAV) is an accelerated form of coronary artery disease responsible for the majority of late deaths after cardiac transplantation. Although most consider this complication a manifestation of chronic allograft rejection, it has not been established whether this disease is a consequence of humoral or cell-mediated alloreactivity.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Human aortic endothelial cells (HAECs) were isolated from donor aortas obtained at the time of organ acquisition for 52 cardiac allograft recipients. Serum and peripheral blood mononuclear cells were obtained from these 52 allograft recipients at several time points during the first year after transplantation. Lymphocyte proliferation (LP) in response to donor-specific HAECs and alloantibody binding to interferon-\u03b3\u2013treated donor-specific HAECs were performed and correlated with clinical parameters, including HLA matching, acute cellular rejection, and coronary artery disease on surveillance angiography. Ten of the 52 patients studied had angiographic or autopsy evidence of coronary artery disease in the first posttransplantation year (CAV+ group). The CAV+ group had higher LP responses to their donor HAECs at 1 week, 3 months, and 6 months after transplantation compared with the CAV\u2212 group (1 week: 1439\u00b1222 versus 824\u00b1141 counts per minute [cpm],\n            <jats:italic>P<\/jats:italic>\n            =.026; 3 months: 1282\u00b1388 versus 884\u00b194 cpm,\n            <jats:italic>P<\/jats:italic>\n            =.07; 6 months: 2504\u00b1635 versus 1540\u00b1209 cpm,\n            <jats:italic>P<\/jats:italic>\n            =.036; CAV+ versus CAV\u2212, respectively). Only 8 of the 52 patients had donor-specific alloantibodies, and there was no relation between antibody presence and CAV. Other clinical parameters that correlated with CAV included the level of HLA-DR mismatch and the presence of late acute rejection.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            CAV is associated with donor-specific cell-mediated alloreactivity to vascular endothelium. Humoral immunity does not appear to have a major role in this disease.\n          <\/jats:p>","DOI":"10.1161\/01.cir.92.2.205","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"205-211","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Cardiac Allograft Vasculopathy"],"prefix":"10.1161","volume":"92","author":[{"given":"Jeffrey D.","family":"Hosenpud","sequence":"first","affiliation":[{"name":"From the Immunobiology Research Laboratory of the Oregon Cardiac Transplant Program; Departments of Medicine and Cell Biology and Anatomy, Oregon Health Sciences University; and Immunology Research, Portland Veterans Affairs Medical Center, Portland, Ore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Everett","sequence":"additional","affiliation":[{"name":"From the Immunobiology Research Laboratory of the Oregon Cardiac Transplant Program; Departments of Medicine and Cell Biology and Anatomy, Oregon Health Sciences University; and Immunology Research, Portland Veterans Affairs Medical Center, Portland, Ore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony E.","family":"Morris","sequence":"additional","affiliation":[{"name":"From the Immunobiology Research Laboratory of the Oregon Cardiac Transplant Program; Departments of Medicine and Cell Biology and Anatomy, Oregon Health Sciences University; and Immunology Research, Portland Veterans Affairs Medical Center, Portland, Ore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly A.","family":"Mauck","sequence":"additional","affiliation":[{"name":"From the Immunobiology Research Laboratory of the Oregon Cardiac Transplant Program; Departments of Medicine and Cell Biology and Anatomy, Oregon Health Sciences University; and Immunology Research, Portland Veterans Affairs Medical Center, Portland, Ore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary D.","family":"Shipley","sequence":"additional","affiliation":[{"name":"From the Immunobiology Research Laboratory of the Oregon Cardiac Transplant Program; Departments of Medicine and Cell Biology and Anatomy, Oregon Health Sciences University; and Immunology Research, Portland Veterans Affairs Medical Center, Portland, Ore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia R.","family":"Wagner","sequence":"additional","affiliation":[{"name":"From the Immunobiology Research Laboratory of the Oregon Cardiac Transplant Program; Departments of Medicine and Cell Biology and Anatomy, Oregon Health Sciences University; and Immunology Research, Portland Veterans Affairs Medical Center, Portland, Ore."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Gao SZ Schroeder JS Alderman EL et al. 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