{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:03:53Z","timestamp":1791295433646,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1995,8,15]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Myocardial blood flow (MBF) impairment has been documented in advanced dilated cardiomyopathy (DCM) in which hemodynamic factors, secondary to severe ventricular dysfunction, may limit myocardial perfusion. To assess whether MBF impairment in DCM may also be present independent of hemodynamic factors, the present study was designed to quantify myocardial perfusion in patients with mild disease without overt heart failure.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Absolute regional MBF (milliliters per minute per gram) was measured by positron emission tomography and\n            <jats:sup>13<\/jats:sup>\n            N-ammonia in resting conditions, during pacing-induced tachycardia, and after dipyridamole infusion (0.56 mg\/kg over 4 minutes) in 22 DCM patients and in 13 healthy subjects. Patients were in New York Heart Association functional class I-II and showed depressed left ventricular (LV) ejection fraction by radionuclide angiography (35\u00b18%; range, 21% to 48%), normal coronary angiography, and normal or moderately increased LV end-diastolic pressure (9.2\u00b15.5 mm Hg; range, 2 to 20 mm Hg). There were no differences in arterial blood pressure, heart rate, and rate-pressure product between patients and control subjects in the three study conditions. Compared with control subjects, DCM patients had lower mean MBF at rest (0.80\u00b10.25 versus 1.08\u00b10.20 mL \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 g\n            <jats:sup>\u22121<\/jats:sup>\n            ,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01), during atrial pacing tachycardia (1.21\u00b10.59 versus 2.03\u00b10.64 mL \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 g\n            <jats:sup>\u22121<\/jats:sup>\n            ,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01), and after dipyridamole infusion (1.91\u00b10.76 versus 3.78\u00b10.86 mL \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 g\n            <jats:sup>\u22121<\/jats:sup>\n            ,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01). LV MBF values were related to baseline LV end-diastolic pressure at rest (\n            <jats:italic>r<\/jats:italic>\n            =\u2212.57,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01) and during pacing (\n            <jats:italic>r<\/jats:italic>\n            =\u2212.67,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01) but not after dipyridamole infusion (\n            <jats:italic>r<\/jats:italic>\n            =.19,\n            <jats:italic>P<\/jats:italic>\n            =.40). Five patients had LV end-diastolic pressure &gt;12 mm Hg; in 4, myocardial perfusion was severely depressed both at baseline and in response to stress.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            In patients with DCM without overt heart failure, myocardial perfusion is impaired both at rest and in response to vasodilating stimuli. The abnormalities in vasodilating capability can be present despite normal hemodynamics; progression of the disease is associated with more depressed myocardial perfusion.\n          <\/jats:p>","DOI":"10.1161\/01.cir.92.4.796","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"796-804","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":171,"title":["Myocardial Blood Flow Response to Pacing Tachycardia and to Dipyridamole Infusion in Patients With Dilated Cardiomyopathy Without Overt Heart Failure"],"prefix":"10.1161","volume":"92","author":[{"given":"Danilo","family":"Neglia","sequence":"first","affiliation":[{"name":"From the Institute of Clinical Physiology of the National Council of Research, Pisa, Italy, and the Istituto di Clinica Medica II (M.L.), University of Pisa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oberdan","family":"Parodi","sequence":"additional","affiliation":[{"name":"From the Institute of Clinical Physiology of the National Council of Research, Pisa, Italy, and the Istituto di Clinica Medica II (M.L.), University of Pisa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Gallopin","sequence":"additional","affiliation":[{"name":"From the Institute of Clinical Physiology of the National Council of Research, Pisa, Italy, and the Istituto di Clinica Medica II (M.L.), University of Pisa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmario","family":"Sambuceti","sequence":"additional","affiliation":[{"name":"From the Institute of Clinical Physiology of the National Council of Research, Pisa, Italy, and the Istituto di Clinica Medica II (M.L.), University of Pisa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assuero","family":"Giorgetti","sequence":"additional","affiliation":[{"name":"From the Institute of Clinical Physiology of the National Council of Research, Pisa, Italy, and the Istituto di Clinica Medica II (M.L.), University of Pisa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Pratali","sequence":"additional","affiliation":[{"name":"From the Institute of Clinical Physiology of the National Council of Research, Pisa, Italy, and the Istituto di Clinica Medica II (M.L.), University of Pisa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Salvadori","sequence":"additional","affiliation":[{"name":"From the Institute of Clinical Physiology of the National Council of Research, Pisa, Italy, and the Istituto di Clinica Medica II (M.L.), University of Pisa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Michelassi","sequence":"additional","affiliation":[{"name":"From the Institute of Clinical Physiology of the National Council of Research, Pisa, Italy, and the Istituto di Clinica Medica II (M.L.), University of Pisa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Lunardi","sequence":"additional","affiliation":[{"name":"From the Institute of Clinical Physiology of the National Council of Research, Pisa, Italy, and the Istituto di Clinica Medica II (M.L.), University of Pisa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gualtiero","family":"Pelosi","sequence":"additional","affiliation":[{"name":"From the Institute of Clinical Physiology of the National Council of Research, Pisa, Italy, and the Istituto di Clinica Medica II (M.L.), University of Pisa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Marzilli","sequence":"additional","affiliation":[{"name":"From the Institute of Clinical Physiology of the National Council of Research, Pisa, Italy, and the Istituto di Clinica Medica II (M.L.), University of Pisa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"L\u2019Abbate","sequence":"additional","affiliation":[{"name":"From the Institute of Clinical Physiology of the National Council of Research, Pisa, Italy, and the Istituto di Clinica Medica II (M.L.), University of Pisa."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.54.3.133002"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.65.4.7199403"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.88.2.8339413"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(83)90205-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)90150-X"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80118-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.81.3.2306829"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(93)90061-D"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(94)90127-9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.86.5.1423973"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.6.1072"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.65.1.7053293"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.51.5.1122593"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.60.3.455621"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90648-7"},{"key":"e_1_3_2_16_2","first-page":"3","volume":"1","year":"1986","unstructured":"Aretz HT, Billingham ME, Edwards WD, Factor SM, Fallon JT, Fenoglio JJ, Olsen EG, Schoen FJ. Myocarditis: a histopathologic definition and classification. Am J Cardiovasc Pathol. 1986;1:3-14.","journal-title":"Am J Cardiovasc Pathol"},{"key":"e_1_3_2_17_2","first-page":"1335","volume":"31","year":"1990","unstructured":"Bellina RC, Parodi O, Camici P, Salvadori PA, Taddei L, Fusani L, Guzzardi R, Klassen GA, L\u2019Abbate A, Donato L. Simultaneous in vitro and in vivo validation of nitrogen-13-ammonia for the assessment of regional myocardial blood flow. J Nucl Med. 1990;31:1335-1343.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.45.6.498444"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/14.1.21"},{"key":"e_1_3_2_20_2","first-page":"H383","volume":"256","year":"1989","unstructured":"Chilian WM, Layne SM, Klausner EC, Eastham CL, Marcus ML. Redistribution of coronary microvascular resistance produced by dipyridamole. Am J Physiol. 1989;256:H383-H390.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(73)90259-2"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.3.1076"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.88.1.8319357"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.68.6.6640870"},{"key":"e_1_3_2_25_2","first-page":"713","volume":"32","year":"1987","unstructured":"Neglia D, Levorato D, Berti S, Marzilli M, Pelosi G, Marcassa C, Bongiorni MG, L\u2019Abbate A, Contini C. Diagnosi e caratterizzazione funzionale di iniziale danno miocardico in pazienti con aritmie cardiache. Cardiologia. 1987;32:713-719.","journal-title":"Cardiologia"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.48.566.732"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","unstructured":"Unverferth DV Baker PB Swift SE Chaffee R Fetters JK Uretsky BF Thompson ME Leier CV. Extent of myocardial fibrosis and cellular hypertrophy in dilated cardiomyopathy. Am J Cardiol.1986;57:816-820.","DOI":"10.1016\/0002-9149(86)90620-X"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.58.2.156"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.66.2.7094244"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90293-3"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80102-0"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80392-7"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(87)90922-7"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90313-5"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.71.2.3965179"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.61.1.7349940"},{"key":"e_1_3_2_37_2","first-page":"1518","volume":"32","year":"1991","unstructured":"Berry JJ, Baker JA, Pieper KS, Hanson MW, Hoffman JM, Coleman RE. The effect of metabolic milieu on cardiac PET imaging using fluorine-18-deoxyglucose and nitrogen-13-ammonia in normal volunteers. J Nucl Med. 1991;32:1518-1525.","journal-title":"J Nucl Med"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.92.4.796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:01:42Z","timestamp":1715529702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.92.4.796"}},"subtitle":["A Quantitative Assessment by Positron Emission Tomography"],"short-title":[],"issued":{"date-parts":[[1995,8,15]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,8,15]]}},"alternative-id":["10.1161\/01.CIR.92.4.796"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.92.4.796","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,8,15]]},"assertion":[{"value":"1995-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-02-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-08-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}