{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:50:36Z","timestamp":1791262236518,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Myocardial reperfusion is pivotal to the prognosis of patients with acute myocardial infarction. In these patients, coronary flow is generally assessed by angiography and tissue perfusion by tracer scintigraphy. This study was designed to examine whether magnetic resonance imaging (MRI) provides information on myocardial perfusion and damage beyond that supplied by angiography and thallium scintigraphy after acute myocardial infarction.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Twenty-two patients with recent myocardial infarction had ECG, echocardiography, coronary angiography, and fast contrast-enhanced MRI. Twelve patients also had exercise thallium scintigraphy. Time-intensity curves obtained from infarcted and noninfarcted regions were correlated with coronary anatomy and left ventricular function. Two perfusion patterns were observed in infarcted regions by comparison with the normal myocardial pattern. All patients but 1 had persistent myocardial hyperenhancement within the infarcted region up to 10 minutes after contrast. In 10 patients, this hyperenhanced region surrounded a subendocardial area of decreased signal at the center of the infarcted region associated with coronary occlusion at angiography, Q waves on ECG, and greater regional dysfunction by echocardiography. Moreover, the extent and location of the MRI abnormalities correlated well with the extent and location of the fixed single-photon emission computed tomography thallium defects.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Large human infarcts, associated with prolonged obstruction of the infarct-related artery, are characterized by central dark zones surrounded by hyperenhanced regions on MRI. Conversely, reperfused infarcts with less regional dysfunction have uniform signal hyperenhancement. The MRI hyperenhanced segment correlates well with the fixed scintigraphic defect in patients with acute myocardial infarction.\n          <\/jats:p>","DOI":"10.1161\/01.cir.92.5.1117","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"1117-1125","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":370,"title":["Regional Heterogeneity of Human Myocardial Infarcts Demonstrated by Contrast-Enhanced MRI"],"prefix":"10.1161","volume":"92","author":[{"given":"Joa\u0303o A. C.","family":"Lima","sequence":"first","affiliation":[{"name":"From the Cardiology Division, Department of Medicine, and the Division of Thoracic and Magnetic Resonance Imaging, Department of Radiology, of the Johns Hopkins Hospital, Baltimore, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Judd","sequence":"additional","affiliation":[{"name":"From the Cardiology Division, Department of Medicine, and the Division of Thoracic and Magnetic Resonance Imaging, Department of Radiology, of the Johns Hopkins Hospital, Baltimore, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Bazille","sequence":"additional","affiliation":[{"name":"From the Cardiology Division, Department of Medicine, and the Division of Thoracic and Magnetic Resonance Imaging, Department of Radiology, of the Johns Hopkins Hospital, Baltimore, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Schulman","sequence":"additional","affiliation":[{"name":"From the Cardiology Division, Department of Medicine, and the Division of Thoracic and Magnetic Resonance Imaging, Department of Radiology, of the Johns Hopkins Hospital, Baltimore, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ergin","family":"Atalar","sequence":"additional","affiliation":[{"name":"From the Cardiology Division, Department of Medicine, and the Division of Thoracic and Magnetic Resonance Imaging, Department of Radiology, of the Johns Hopkins Hospital, Baltimore, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias A.","family":"Zerhouni","sequence":"additional","affiliation":[{"name":"From the Cardiology Division, Department of Medicine, and the Division of Thoracic and Magnetic Resonance Imaging, Department of Radiology, of the Johns Hopkins Hospital, Baltimore, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"871","volume":"1","year":"1986","unstructured":"Gruppo Italiano per lo Studio della Streptochinasi nell\u2019Infarto Miocardico (GISSI). Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet. 1986;1:871-874.","journal-title":"Lancet"},{"key":"e_1_3_2_2_2","first-page":"349","volume":"2","year":"1988","unstructured":"ISIS 2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet. 1988;2:349-360.","journal-title":"Lancet"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511283132204"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91893-D"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.76.1.142"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90095-5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199303113281003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80381-8"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.5.1699"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910130114"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90754-W"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90754-M"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.160.2.3726135"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.4.2791255"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90477-9"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.172.1.2500678"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330211"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90363-2"},{"key":"e_1_3_2_19_2","unstructured":"Judd RM Reeder SB Atalar E McVeigh ER Zerhouni EA. A magnetization-driven gradient echo pulse sequence from the Study of Myocardial Perfusion. Magn Reson Med. In press."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910210210"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.71.5.1048"},{"key":"e_1_3_2_22_2","unstructured":"Winer BJ. Statistical Principles in Experimental Design. 2nd ed. New York NY: McGraw Hill; 1971:351-359."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910200212"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910220205"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108421"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.55.1.830221"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.6.2598442"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107898"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.172.3.2772179"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.66.5.6181904"},{"key":"e_1_3_2_31_2","first-page":"82","volume":"4","year":"1989","unstructured":"Nishimura T, Yamada Y, Hayashi M, Kozuka T, Nakatani T, Noda H, Takano H. Determination of infarct size of acute myocardial infarction in dogs by magnetic resonance imaging and gadolinium-DTPA: comparison with indium-111 antimyosin imaging. Am J Physiol Imaging. 1989;4:82-88.","journal-title":"Am J Physiol Imaging"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90569-X"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290410"},{"key":"e_1_3_2_34_2","first-page":"97","volume":"10","year":"1992","unstructured":"Wedeking P, Sotak CH, Telser J, Kumar K, Chang CA, Tweedle MF. Quantitative dependence of MR signal intensity on tissue concentration of Gd(HP-DO3A) in the nephrectomized rat. Magn Reson Med. 1992;10:97-108.","journal-title":"Magn Reson Med"},{"key":"e_1_3_2_35_2","unstructured":"Crone C Levitt DG. Capillary permeability to small solutes. In: Renkin EM Michel CC Geiger SR eds. Handbook of Physiology. Bethesda Md: American Physiological Society; 1984: section 2 vol IV part II 411-439."},{"key":"e_1_3_2_36_2","unstructured":"Wolf G. Contrast agents for cardiac MRI. In: Marcus M Skorton D Schelbert H Wolf G eds. Cardiac Imaging. Philadelphia Pa: WB Saunders Co; 1991:794-810."}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.92.5.1117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:41:53Z","timestamp":1715528513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.92.5.1117"}},"subtitle":["Potential Mechanisms"],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1161\/01.CIR.92.5.1117"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.92.5.1117","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]},"assertion":[{"value":"1994-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}