{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:35:04Z","timestamp":1791106504118,"version":"4.1.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            The feasibility of radiofrequency (RF) catheter ablation for the treatment of sustained ventricular tachycardia (VT) in patients with coronary artery disease and remote myocardial infarction has recently been demonstrated. At present, therapeutic options for VT in patients with idiopathic dilated cardiomyopathy (DCM) include antiarrhythmic drugs and implantable cardioverter\/defibrillators (ICD). The purpose of the present study was to investigate the feasibility of RF catheter ablation in patients with idiopathic DCM who could not be adequately treated by conventional treatment modalities because of incessant or frequent, recurrent VT.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            RF current application for ablation of 9 VTs (mean cycle length, 402\u00b178 ms) was attempted in 8 patients with idiopathic DCM (4 men, 4 women; mean age, 54\u00b16 years; mean left ventricular ejection fraction, 30\u00b19%). Inclusion criteria for ablation were incessant VT (n=4) or frequent, recurrent VT reproducibly inducible with programmed electrical stimulation (n=5). Three patients had suffered aborted sudden cardiac death, and 2 had experienced syncope. Two patients were artificially ventilated and catecholamine dependent for hemodynamic reasons at the time of attempted ablation. Potential target sites for RF current application were identified by detailed endocardial mapping during sinus rhythm, activation and entrainment mapping during VT, and pace mapping. After 7\u00b15 RF pulses (range, 2 to 18 pulses; median, 6 pulses) applied with 32\u00b17 W for 39\u00b19 seconds, 6 of the 9 target VTs (67%) were rendered noninducible (4 of 4 incessant VTs and 2 of 5 chronic recurrent VTs). In 6 patients, VTs with ECG morphologies other than the target VTs were inducible after RF catheter ablation. Seven patients were on antiarrhythmic drugs during the ablation procedure and during the follow-up period of 8\u00b15 months (range, 2 to 17 months). One patient received an ICD before RF ablation, 4 patients after RF ablation, and 1 patient after ablation of an incessant VT and before attempted ablation of frequent, recurrent VTs. One patient underwent heart transplantation 5 months after ablation in end-stage heart failure. There were no acute complications during the mapping and ablation procedure. During the follow-up period, 1 patient had been resuscitated from ventricular fibrillation 6 weeks after ablation and finally died of congestive heart failure 2 weeks later. No further episodes of incessant VT occurred in the patients who had undergone RF current application for ablation of incessant VT. A complete prevention of VT could be achieved in 2 of 8 patients, whereas in 5 patients, VT episodes were stored in the ICD devices during follow-up.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            The results of the present study indicate that RF current application for ablation of VT in a select group of patients with idiopathic DCM is feasible. The efficacy of RF ablation may be high in patients presenting with incessant VT, whereas the success rate seems to be only moderate in patients with chronic recurrent VT. In all patients, additional treatment options, including antiarrhythmic drugs, ICDs, and\/or heart transplantation, were applied after RF ablation, indicating that RF ablation for this indication may be an adjunctive and not a curative treatment option.\n          <\/jats:p>","DOI":"10.1161\/01.cir.92.5.1159","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"1159-1168","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":79,"title":["Radiofrequency Catheter Ablation of Sustained Ventricular Tachycardia in Idiopathic Dilated Cardiomyopathy"],"prefix":"10.1161","volume":"92","author":[{"given":"Hans","family":"Kottkamp","sequence":"first","affiliation":[{"name":"From the Hospital of the Westfa\u0308lische Wilhelms-University, Department of Cardiology and Angiology, and Institute for Arteriosclerosis Research, Mu\u0308nster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[{"name":"From the Hospital of the Westfa\u0308lische Wilhelms-University, Department of Cardiology and Angiology, and Institute for Arteriosclerosis Research, Mu\u0308nster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Hospital of the Westfa\u0308lische Wilhelms-University, Department of Cardiology and Angiology, and Institute for Arteriosclerosis Research, Mu\u0308nster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u0308rgen","family":"Brunn","sequence":"additional","affiliation":[{"name":"From the Hospital of the Westfa\u0308lische Wilhelms-University, Department of Cardiology and Angiology, and Institute for Arteriosclerosis Research, Mu\u0308nster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Willems","sequence":"additional","affiliation":[{"name":"From the Hospital of the Westfa\u0308lische Wilhelms-University, Department of Cardiology and Angiology, and Institute for Arteriosclerosis Research, Mu\u0308nster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Haverkamp","sequence":"additional","affiliation":[{"name":"From the Hospital of the Westfa\u0308lische Wilhelms-University, Department of Cardiology and Angiology, and Institute for Arteriosclerosis Research, Mu\u0308nster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Block","sequence":"additional","affiliation":[{"name":"From the Hospital of the Westfa\u0308lische Wilhelms-University, Department of Cardiology and Angiology, and Institute for Arteriosclerosis Research, Mu\u0308nster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu\u0308nter","family":"Breithardt","sequence":"additional","affiliation":[{"name":"From the Hospital of the Westfa\u0308lische Wilhelms-University, Department of Cardiology and Angiology, and Institute for Arteriosclerosis Research, Mu\u0308nster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Borggrefe","sequence":"additional","affiliation":[{"name":"From the Hospital of the Westfa\u0308lische Wilhelms-University, Department of Cardiology and Angiology, and Institute for Arteriosclerosis Research, Mu\u0308nster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80200-0"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106063242301"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93258-B"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106063242302"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207303270504"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90519-F"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.85.5.1572025"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.1.8418999"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.88.6.8252671"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.4.8149535"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90375-1"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.88.4.8403311"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.2.8425285"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.3.8124795"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90147-3"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1993.tb01039.x"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.84.3.1884439"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.83.5.2022017"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.86.6.1451259"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90002-9"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90003-0"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.77.4.3349582"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90232-5"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80184-6"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90815-1"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.52.2.6218936"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a062144"},{"key":"e_1_3_1_28_2","first-page":"401","volume":"13","year":"1986","unstructured":"Fontaine G, Frank R, Tonet JL, Gallais Y, Touzet I, Todorova M, Baraka M, Grosgogeat Y. Treatment of resistant ventricular tachycardia with endocavitary fulguration and antiarrhythmic therapy, compared to antiarrhythmic therapy alone: experience in 111 consecutive cases with a mean follow-up of 18 months. Tex Heart Inst J. 1986;13:401-418.","journal-title":"Tex Heart Inst J"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.75.5.3568304"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1992.tb05137.x"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706043162301"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250501"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250502"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90900-J"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90308-N"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.6.2598430"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90618-7"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.72.3.4017211"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.56.3.3971515"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)92832-M"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a062078"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.4.8462136"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(86)80025-X"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1988.tb04551.x"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060383"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1993.tb01228.x"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90503-F"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1991.tb01323.x"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90453-T"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(86)90010-4"},{"key":"e_1_3_1_51_2","unstructured":"Perlman RL Miller J Kindwall KE Buxton AE Josephson ME Marchlinski FE. Abnormal epicardial and endocardial electrograms in patients with idiopathic dilated cardiomyopathy: relationship to arrhythmias. Circulation. 1990;82(suppl III):III-708. Abstract."},{"key":"e_1_3_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90556-8"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.92.5.1159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:42:00Z","timestamp":1715528520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.92.5.1159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1161\/01.CIR.92.5.1159"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.92.5.1159","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]},"assertion":[{"value":"1995-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-02-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}