{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:12:09Z","timestamp":1768677129204,"version":"3.49.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1995,10,15]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            The present study considered the uniformity and durability of the cardiopulmonary response to single lung transplantation in patients with severe pulmonary hypertension, as well as its effect on length and quality of survival.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Thirty-four patients with pulmonary hypertension underwent evaluation, single lung transplantation, and follow-up assessment between November 1, 1989, and June 1, 1994. Operative survival for the entire group of patients was reasonable, with 91% (31 of 34 patients) surviving and being discharged from the hospital following transplantation. The actuarial survival for these 34 patients at 1-, 2-, and 3-year follow-up was 78%, 66%, and 61%, respectively. In the subgroup of 24 patients with primary pulmonary hypertension (PPH), 96% (23 of 24) were successfully discharged from the hospital after transplantation. The actuarial survival for this isolated PPH subgroup at 1-, 2-, and 3-year follow-up was 87%, 76%, and 68%, respectively. The uniform, early posttransplant normalization of pulmonary vascular resistance and right ventricular ejection fraction appears to persist throughout the 4-year follow-up period. Despite a high prevalence of bronchiolitis obliterans, the majority of survivors remain in New York Heart Association functional class I or II and are employed.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Single lung transplantation can be performed in patients with end-stage pulmonary vascular disease with reasonable expectations for a relatively low operative mortality; immediate, complete, and durable amelioration of pulmonary hypertension and right ventricular failure; and optimal use of limited donor organ supply.\n          <\/jats:p>","DOI":"10.1161\/01.cir.92.8.2252","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"2252-2258","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":134,"title":["Single Lung Transplantation for Pulmonary Hypertension"],"prefix":"10.1161","volume":"92","author":[{"given":"Michael K.","family":"Pasque","sequence":"first","affiliation":[{"name":"From the Division of Cardiothoracic Surgery, Division of Pulmonary Medicine, and Division of Cardiothoracic Anesthesiology, Washington University Medical Center at Barnes Hospital, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elbert P.","family":"Trulock","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Surgery, Division of Pulmonary Medicine, and Division of Cardiothoracic Anesthesiology, Washington University Medical Center at Barnes Hospital, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel D.","family":"Cooper","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Surgery, Division of Pulmonary Medicine, and Division of Cardiothoracic Anesthesiology, Washington University Medical Center at Barnes Hospital, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasios N.","family":"Triantafillou","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Surgery, Division of Pulmonary Medicine, and Division of Cardiothoracic Anesthesiology, Washington University Medical Center at Barnes Hospital, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B.","family":"Huddleston","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Surgery, Division of Pulmonary Medicine, and Division of Cardiothoracic Anesthesiology, Washington University Medical Center at Barnes Hospital, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rosenbloom","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Surgery, Division of Pulmonary Medicine, and Division of Cardiothoracic Anesthesiology, Washington University Medical Center at Barnes Hospital, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir","family":"Sundaresan","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Surgery, Division of Pulmonary Medicine, and Division of Cardiothoracic Anesthesiology, Washington University Medical Center at Barnes Hospital, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Cox","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Surgery, Division of Pulmonary Medicine, and Division of Cardiothoracic Anesthesiology, Washington University Medical Center at Barnes Hospital, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Alexander","family":"Patterson","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Surgery, Division of Pulmonary Medicine, and Division of Cardiothoracic Anesthesiology, Washington University Medical Center at Barnes Hospital, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470140055023"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-4-560"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)34988-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.84.6.1959182"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"e_1_3_2_6_2","first-page":"713","volume":"12","year":"1993","unstructured":"Cooper JD, Billingham M, Egan T, Hertz MI, Higenbottam T, Lynch J, Mauer J, Paradis I, Patterson GA, Smith C, Trulock EP, Vreim C, Yousem S, for the International Society for Heart and Lung Transplantation. A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts. J Heart Lung Transplant. 1993;12:713-716.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_2_7_2","unstructured":"Wilkinson L. SYSTAT: The System for Statistics. Evanston Ill: SYSTAT Inc; 1989."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207093270203"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/140.6.1623"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-7-485"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198203113061001"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02470657"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)35632-6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/1010-7940(89)90027-4"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.92.8.2252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:31:41Z","timestamp":1715527901000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.92.8.2252"}},"subtitle":["Single Institution Experience in 34 Patients"],"short-title":[],"issued":{"date-parts":[[1995,10,15]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1995,10,15]]}},"alternative-id":["10.1161\/01.CIR.92.8.2252"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.92.8.2252","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10,15]]},"assertion":[{"value":"1995-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-05-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-10-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}