{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:43:18Z","timestamp":1789720998753,"version":"4.0.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1995,10,15]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Intra-arterial gamma irradiation has been shown to reduce restenosis after balloon angioplasty. The use of beta emitters should allow similar effects while inducing less undue tissue irradiation radioprotection problems.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Flexible 90-yttrium (\n            <jats:sup>90<\/jats:sup>\n            Y) coils inside a centering balloon were used to allow homogeneous intra-arterial dose delivery. One carotid and one iliac artery of 21 hypercholesterolemic rabbits were deendothelialized and then irradiated. Four dose schedules were studied: (1) control (dilated, nonirradiated); (2) 6 Gy; (3) 12 Gy; and (4) 18 Gy. Arterial specimens were histologically evaluated at 8 days and at 6 weeks. For all radiation doses at 8 days compared with controls, there was a significant decrease in bromodeoxyuridine-labeled cells (245\u00b193 cells\/cm in control, 42\u00b127 in 6 Gy, 72\u00b1107 in 12 Gy, and 2\u00b12 in 18 Gy groups;\n            <jats:italic>P<\/jats:italic>\n            &lt;.001) and in total neointimal cells (891\u00b1415 cells\/cm in control, 79\u00b143 in 6 Gy, 192\u00b1264 in 12 Gy and 22\u00b113 in 18 Gy groups;\n            <jats:italic>P<\/jats:italic>\n            &lt;.0002). At 6 weeks, computer-derived histological percent area stenosis was reduced from 26\u00b110% in the control group to 1\u00b11.3% in the 18 Gy group (\n            <jats:italic>P<\/jats:italic>\n            &lt;.0001), but lower doses had no significant effect.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Administration of intra-arterial beta irradiation with a\n            <jats:sup>90<\/jats:sup>\n            Y source is technically feasible and compatible with an ordinary catheterization laboratory environment. A dose of 18 Gy effectively induces long-term inhibition of neointimal hyperplasia.\n          <\/jats:p>","DOI":"10.1161\/01.cir.92.8.2284","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"2284-2290","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":142,"title":["Intra-arterial Beta Irradiation Prevents Neointimal Hyperplasia in a Hypercholesterolemic Rabbit Restenosis Model"],"prefix":"10.1161","volume":"92","author":[{"given":"Vitali","family":"Verin","sequence":"first","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. Rouzaud, P.N., E.G., J.M.K.), University Hospital, Geneva, Switzerland; and Schneider (Europe) AG (M.S.), Bu\u0308lach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youri","family":"Popowski","sequence":"additional","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. Rouzaud, P.N., E.G., J.M.K.), University Hospital, Geneva, Switzerland; and Schneider (Europe) AG (M.S.), Bu\u0308lach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Urban","sequence":"additional","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. Rouzaud, P.N., E.G., J.M.K.), University Hospital, Geneva, Switzerland; and Schneider (Europe) AG (M.S.), Bu\u0308lach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Belenger","sequence":"additional","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. Rouzaud, P.N., E.G., J.M.K.), University Hospital, Geneva, Switzerland; and Schneider (Europe) AG (M.S.), Bu\u0308lach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Redard","sequence":"additional","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. Rouzaud, P.N., E.G., J.M.K.), University Hospital, Geneva, Switzerland; and Schneider (Europe) AG (M.S.), Bu\u0308lach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Costa","sequence":"additional","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. Rouzaud, P.N., E.G., J.M.K.), University Hospital, Geneva, Switzerland; and Schneider (Europe) AG (M.S.), Bu\u0308lach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claude","family":"Widmer","sequence":"additional","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. Rouzaud, P.N., E.G., J.M.K.), University Hospital, Geneva, Switzerland; and Schneider (Europe) AG (M.S.), Bu\u0308lach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Rouzaud","sequence":"additional","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. Rouzaud, P.N., E.G., J.M.K.), University Hospital, Geneva, Switzerland; and Schneider (Europe) AG (M.S.), Bu\u0308lach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Nouet","sequence":"additional","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. Rouzaud, P.N., E.G., J.M.K.), University Hospital, Geneva, Switzerland; and Schneider (Europe) AG (M.S.), Bu\u0308lach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euge\u0300ne","family":"Grob","sequence":"additional","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. Rouzaud, P.N., E.G., J.M.K.), University Hospital, Geneva, Switzerland; and Schneider (Europe) AG (M.S.), Bu\u0308lach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schwager","sequence":"additional","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. Rouzaud, P.N., E.G., J.M.K.), University Hospital, Geneva, Switzerland; and Schneider (Europe) AG (M.S.), Bu\u0308lach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Kurtz","sequence":"additional","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. Rouzaud, P.N., E.G., J.M.K.), University Hospital, Geneva, Switzerland; and Schneider (Europe) AG (M.S.), Bu\u0308lach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Rutishauser","sequence":"additional","affiliation":[{"name":"From the Cardiology Center (V.V., P.U., J.B., M. Redard, M.C., M.-C.W., W.R.) and Division of Radiation Oncology (Y.P., M. 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